2026-04-18T07:03:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/81732025-10-24T10:59:16Zcom_2072_451665com_2072_378040col_2072_451666

SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis Jesús Gil, Carmen de García-Jiménez, Irene Sans De San Nicolàs, Lídia Figueras, Ignasi Guilabert, Antonio Bonfill Ortí, Montserrat [Sans-De San Nicolàs L, De Jesús-Gil C, García-Jiménez I] Grup d’Immunologia Translacional, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc Científic de Barcelona (PCB), Barcelona, Spain. [Figueras-Nart I, Bonfill-Ortí M] Departament de Dermatologia, Hospital de Bellvitge, Universitat de Barcelona (UB), L’Hospitalet de Llobregat, Spain. [Guilabert A] Departament de Dermatologia, Hospital General de Granollers, Granollers, Spain Hospital General de Granollers Dermatitis atòpica Estafilococs daurats Pell - Infeccions DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Dermatitis::Skin and Connective Tissue Diseases::Skin Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Dermatitis, Atopic ORGANISMS::Bacteria::Bacteria::Firmicutes::Bacillales::Staphylococcaceae::Staphylococcus::Bacteria::Bacteria::Staphylococcus aureus ANATOMY::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatitis::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatitis atópica ORGANISMOS::Bacteria::Bacteria::Firmicutes::Bacillales::Staphylococcaceae::Staphylococcus::Bacteria::Bacteria::Staphylococcus aureus ANATOMÍA::células::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients. 2022-09-13T07:23:21Z 2022-09-13T07:23:21Z 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Sans-De San Nicolàs L, Figueras-Nart I, Bonfill-Ortí M, De Jesús-Gil C, García-Jiménez I, Guilabert A, et al. SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis. Allergy. 2022 Jun 30. https://hdl.handle.net/11351/8173 10.1111/all.15424 35773619 http://hdl.handle.net/11351/8173 eng Allergy; https://doi.org/10.1111/all.15424 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf Wiley Scientia