2026-04-13T02:43:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/81732025-10-24T10:59:16Zcom_2072_451665com_2072_378040col_2072_451666

00925njm 22002777a 4500 dc Jesús Gil, Carmen de author García-Jiménez, Irene author Sans De San Nicolàs, Lídia author Figueras, Ignasi author Guilabert, Antonio author Bonfill Ortí, Montserrat author 2022-09-13T07:23:21Z 2022-09-13T07:23:21Z 2022-06-30 Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients. http://hdl.handle.net/11351/8173 Dermatitis atòpica Estafilococs daurats Pell - Infeccions DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Dermatitis::Skin and Connective Tissue Diseases::Skin Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Dermatitis, Atopic ORGANISMS::Bacteria::Bacteria::Firmicutes::Bacillales::Staphylococcaceae::Staphylococcus::Bacteria::Bacteria::Staphylococcus aureus ANATOMY::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatitis::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatitis atópica ORGANISMOS::Bacteria::Bacteria::Firmicutes::Bacillales::Staphylococcaceae::Staphylococcus::Bacteria::Bacteria::Staphylococcus aureus ANATOMÍA::células::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis