2026-04-13T18:47:16Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/81252025-09-30T02:07:27Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Mirallas Viñas, Oriol
author
López-Valbuena, D.
author
García Illescas, David
author
Verdaguer Mata, Helena
author
Tabernero Caturla, Josep
author
Fabregat Franco, Carles
author
Macarulla Mercadé, Teresa
2022-09-09T13:30:21Z2022-09-09T13:30:21Z2022-06
Biliary tract cancer; Molecular testing; Next-generation sequencingCáncer del tracto biliar; Pruebas moleculares; Secuenciación de nueva generaciónCàncer del tracte biliar; Proves moleculars; Seqüenciació de nova generacióIntroduction
Biliary tract cancers (BTCs) are a rare and heterogenous group with an increasing incidence and high mortality rate. The estimated new cases and deaths of BTC worldwide are increasing, but the incidence and mortality rates in South East Asia are the highest worldwide, representing a real public health problem in these regions. BTC has a poor prognosis with a median overall survival <12 months. Thus, an urgent unmet clinical need for BTC patients exists and must be addressed.
Results
The backbone treatment of these malignancies is chemotherapy in first- and second-line setting, but in the last decade a rich molecular landscape has been discovered, expanding conceivable treatment options. Some druggable molecular aberrations can be treated with new targeted therapies and have already demonstrated efficacy in patients with BTC, improving clinical outcomes, such as the FGFR2 or IDH1 inhibitors. Many other molecular alterations are being discovered and the treatment of BTC will change in the near future from our current clinical practice.
Conclusions
In this review we discuss the epidemiology, molecular characteristics, present treatment approaches, review the recent therapeutic advances, and explore future directions for patients with BTC. Due to the rich molecular landscape of BTC, molecular profiling should be carried out early. Ongoing research will bring new targeted treatments and immunotherapy in the near future.
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Tracte biliar - Càncer - Tractament
Farmacologia molecular
Immunoteràpia
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Biliary Tract Neoplasms
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Molecular Targeted Therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias del tracto biliar
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::terapia molecular selectiva
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
Advances in the systemic treatment of therapeutic approaches in biliary tract cancer
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion