2026-04-17T17:29:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/79182025-11-13T19:23:56Zcom_2072_378071com_2072_378040col_2072_378097

Impact of central venous pressure on the mortality of patients with sepsis-related acute kidney injury: a propensity score-matched analysis based on the MIMIC IV database Huo, Yan Li, Bo Rello Condomines, Jordi Kim, Won-Young Wang, Xiaoting Hu, Zhenjie Wang, Xinrui Institut Català de la Salut [Huo Y, Wang X, Li B, Hu Z] Department of Intensive Care Unit, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, China. [Rello J] Grup de Recerca Clínica/Innovació en la Pneumònia i Sèpsia (CRIPS), Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Barcelona, Spain & Clinical Research, CHU Nîmes, Nimes, France. [Kim WY] Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. [Wang X] Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China Vall d'Hebron Barcelona Hospital Campus Insuficiència renal aguda - Complicacions Septicèmia DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injury Other subheadings::Other subheadings::Other subheadings::/complications ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::lesión renal aguda Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones Central venous pressure (CVP); Database; Mortality Pressió venosa central (PVC); Base de dades; Mortalitat Presión venosa central (PVC); Base de datos; Mortalidad Background: Sepsis has long been a life-threatening organ dysfunction. Sepsis associated acute kidney injury (SA-AKI) is an important complication of sepsis, as an important hemodynamic index, the impact of central venous pressure (CVP) on sepsis patients needs to be explored. Thus this study aimed to investigate the relationship between CVP and the mortality of SA-AKI. Methods: Clinical data of adult patients with sepsis-related acute kidney injury, defined as met both the Sepsis 3.0 criteria and the Kidney Disease Improving Global Outcomes Clinical Practice Guideline (KDIGO) criteria, were obtained from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. The included cohort was divided into a high CVP and a low CVP group were determined based on the cuf-off value from receiver operating characteristic curve, with propensity score-matched analysis of the 28-day mortality for both groups and sensitivity analysis using inverse the probability-weighting model, multifactorial regression, and doubly robust estimation, patients acquired chronic coronary syndrome (CCS) and diabetes were also taken into consideration. Results: Of 1,377 patients with sepsis-related acute kidney injury, low CVP group (<13 mmHg) was 67.4% (n=928) and high CVP group (≥13 mmHg) was 32.6% (n=449). The two groups were matched 1:1 by propensity score to obtain a matched cohort (n=288). The mortality rates in the low versus high CVP group (19.4% vs. 34.7%) were statistically difference (odds ratio OR: 0.454; 95% confidence interval 0.263, 0.771). Moreover, the bistable analysis of logistic regression of the matched cohort (OR: 0.434; 95% CI: 0.244, 0.757), propensity score inverse probability weighting (IPW) (OR: 0.547; 95% CI: 0.454, 0.658), and multifactorial logistic regression (OR: 0.352; 95% CI: 0.127, 0.932) all yielded the same results. Conclusions: In patients with sepsis-related acute kidney injury, a lower CVP level (<13 mmHg) is an independent variable associated with decreased mortality. The threshold of CVP needs to be controlled in clinical work to improve the prognosis of patients with SA-AKI. 2022-07-25T09:37:35Z 2022-07-25T09:37:35Z 2022-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Huo Y, Wang X, Li B, Rello J, Kim WY, Wang X, et al. Impact of central venous pressure on the mortality of patients with sepsis-related acute kidney injury: a propensity score-matched analysis based on the MIMIC IV database. Ann Transl Med. 2022 Feb;10(4):199. 2305-5847 https://hdl.handle.net/11351/7918 10.21037/atm-22-588 35280402 000762330100001 eng Annals of Translational Medicine;10(4) https://dx.doi.org/10.21037/atm-22-588 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf AME Publishing Company Scientia