2026-04-17T21:38:01Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/78522024-06-06T13:33:01Zcom_2072_378071com_2072_378040col_2072_378097

Long-Term Risk of Mortality Associated with Isolation of Pseudomonas aeruginosa in COPD: A Systematic Review and Meta-Analysis Barrecheguren Fernández, Miriam García-Ortega, Alberto Nuñez Dubon, Alexa Gabriela Oscullo, Grace Miravitlles Fernández, Marc Rigau, David Martinez-Garcia, Miguel Angel Institut Català de la Salut [Martinez-García MA] Pneumology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. [Rigau D] Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain. [Barrecheguren M, Nuñez A, Miravitlles M] CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [García-Ortega A, Oscullo Yepez G] Pneumology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain Vall d'Hebron Barcelona Hospital Campus Pseudomones aeruginosa Pulmons - Malalties obstructives - Prognosi DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica COPD; Bronchial infection; Mortality EPOC; Infección bronquial; Mortalidad MPOC; Infecció bronquial; Mortalitat Background: Chronic bronchial infection is frequent in chronic obstructive pulmonary disease (COPD), but the impact of the isolation of pathogenic bacteria, and in particular Pseudomonas aeruginosa (PA) in respiratory samples on the prognosis of COPD is unclear. Methods: We conducted a systematic review of prognostic studies including patients with isolation of PA in sputum in stable state or during exacerbations of COPD. The main outcomes were all-cause mortality, respiratory mortality, and number and severity of future exacerbations. Data were expressed as hazard ratio (HR) (95% confidence interval [CI]) whenever possible. Results: Of 2773 studies, eight were finally included (23,228 individuals). The mean age ranged from 65.5 to 73 years. Six studies reported data for all-cause mortality. The adjusted risk of death was almost double in patients with PA isolation (HR 1.95, 95% CI, 1.34 to 2.84; quality of evidence moderate). Patients with PA isolation showed a three times higher adjusted risk of readmission at 30 days after discharge (OR 3.60, 95% CI, 3.60 to 12.03, 1 study; quality of evidence very low), and more than double adjusted risk of death and hospitalization at two years (HR 2.80, 95% CI, 2.20 to 3.56, 1 study; quality of evidence very low). Conclusion: There is moderate certainty that the isolation of PA in sputum is associated with an adjusted increased risk of death in patients with COPD. This study has been funded by an unrestricted grant from Boehringer Ingelheim Spain. 2022-07-20T07:32:06Z 2022-07-20T07:32:06Z 2022-02-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martinez-García MA, Rigau D, Barrecheguren M, García-Ortega A, Nuñez A, Oscullo Yepez G, et al. Long-Term Risk of Mortality Associated with Isolation of Pseudomonas aeruginosa in COPD: A Systematic Review and Meta-Analysis. Int J Chron Obstruct Pulmon Dis. 2022 Feb 16;17:371–82. 1178-2005 https://hdl.handle.net/11351/7852 10.2147/COPD.S346294 35210766 000759894100003 eng International Journal of Chronic Obstructive Pulmonary Disease;17 http://dx.doi.org/10.2147/COPD.S346294 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf Dove Medical Press Scientia