2026-04-17T01:18:06Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/77962025-10-24T10:30:42Zcom_2072_378070com_2072_378040col_2072_378092

Health economic impact of first-pass success among patients with acute ischemic stroke treated with mechanical thrombectomy: a United States and European perspective Ribó Jacobi, Marc Mattle, Heinrich Saver, Jeffrey L. Bozorgchami, Hormozd Yoo, Albert J. Zaidat, Osama Institut Català de la Salut [Zaidat OO] Department of Neuroscience, Mercy Saint Vincent Medical Center, Toledo, Ohio, USA. [Ribo M] Unitat d’Ictus, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Mattle HP] Department of Neurology, Inselspital, University of Bern, Bern, Switzerland. [Saver JL] Department of Neurology, UCLA, Los Angeles, California, USA. [Bozorgchami H] Oregon Health and Science University, Portland, Oregon, USA. [Yoo AJ] Department of Neurointervention, Texas Stroke Institute, Plano, Texas, USA Vall d'Hebron Barcelona Hospital Campus Malalties cerebrovasculars - Cirurgia Avaluació de resultats (Assistència sanitària) Vasos sanguinis - Cirurgia DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Brain Ischemia Other subheadings::Other subheadings::Other subheadings::/surgery ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::isquemia cerebral Otros calificadores::Otros calificadores::Otros calificadores::/cirugía Economics; Stroke; Thrombectomy Economia; Ictus; Trombectomia Economía; Ictus; Trombectomía Background First-pass effect (FPE), restoring complete or near complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2c-3) in a single pass, is an independent predictor for good functional outcomes in the endovascular treatment of acute ischemic stroke. The economic implications of achieving FPE have not been assessed. Objective To assess the economic impact of achieving complete or near complete reperfusion after the first pass. Methods Post hoc analyses were conducted using ARISE II study data. The target population consisted of patients in whom mTICI 2c–3 was achieved, stratified into two groups: (1) mTICI 2c–3 achieved after the first pass (FPE group) or (2) after multiple passes (non-FPE group). Baseline characteristics, clinical outcomes, and healthcare resource use were compared between groups. Costs from peer-reviewed literature were applied to assess cost consequences from the perspectives of the United States (USA), France, Germany, Italy, Spain, Sweden, and United Kingdom (UK). Results Among patients who achieved mTICI 2c–3 (n=172), FPE was achieved in 53% (n=91). A higher proportion of patients in the FPE group reached good functional outcomes (90-day modified Rankin Scale score 0–2 80.46% vs 61.04%, p<0.01). The patients in the FPE group had a shorter mean length of stay (6.10 vs 9.48 days, p<0.01) and required only a single stent retriever, whereas 35% of patients in the non-FPE group required at least one additional device. Driven by improvement in clinical outcomes, the FPE group had lower procedural/hospitalization-related (24–33% reduction) and annual care (11–27% reduction) costs across all countries. Conclusions FPE resulted in improved clinical outcomes, translating into lower healthcare resource use and lower estimated costs. This study was funded by Cerenovus, a subsidiary of Johnson and Johnson. 2022-07-18T14:17:20Z 2022-07-18T14:17:20Z 2021-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Zaidat OO, Ribo M, Mattle HP, Saver JL, Bozorgchami H, Yoo AJ, et al. Health economic impact of first-pass success among patients with acute ischemic stroke treated with mechanical thrombectomy: a United States and European perspective. J Neurointerv Surg. 2021 Dec;13(12):1117-1123. 1759-8486 https://hdl.handle.net/11351/7796 10.1136/neurintsurg-2020-016930 33443119 000722239300010 http://hdl.handle.net/11351/7796 eng Journal of NeuroInterventional Surgery;13(12) http://dx.doi.org/10.1136/neurintsurg-2020-016930 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf BMJ Scientia