2026-04-13T15:16:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/76762025-10-24T10:38:56Zcom_2072_378070com_2072_378040col_2072_378092

Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL) Haferlach, Claudia Meggendorfer, Manja Barba Suñol, Pere Morgades, Mireia Genescà, Eulàlia González Gil, Celia Fuster-Tormo, Francisco Institut Català de la Salut [Genescà E, González-Gil C, Fuster-Tormo F] Josep Carreras Leukaemia Research Institute (IJC), Campus ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Badalona, Spain. [Morgades M] Josep Carreras Leukaemia Research Institute (IJC), Campus ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Badalona, Spain. Clinical Hematology Department, ICO-Hospital Germans Trias i Pujol, Badalona, Spain. [Haferlach C, Meggendorfer M] MLL Munich Leukemia Laboratory, Munich, Germany. [Barba P] Servei d’Hematologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Leucèmia limfoblàstica - Prognosi Anomalies cromosòmiques DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Mutation::Chromosome Aberrations ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia linfoide::leucemia-linfoma linfoblástico de células precursoras TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::mutación::aberraciones cromosómicas Cytogenetics; Prognosis; Therapy Citogenética; Pronóstico; Terapia Citogenètica; Pronòstic; Teràpia The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. Complex karyotype defined by the presence of ≥3 cytogenetic alterations identified T-ALL patients with poor prognosis in this study. Karyotypes with ≥3 abnormalities accounted for 16 % (22/139) of all evaluable karyotypes, corresponding to the largest poor prognosis cytogenetic subgroup of T-ALL identified so far. Patients carrying karyotypes with ≥3 cytogenetic alterations showed a significantly inferior response to therapy, and a poor outcome in terms of event-free survival (EFS), overall survival (OS) and cumulative incidence of relapse (CIR), independently of other baseline characteristics and the end-induction minimal residual disease (MRD) level. Additional molecular analyses of patients carrying ≥3 cytogenetic alterations showed a unique molecular profile that could contribute to understand the underlying molecular mechanisms of resistance and to evaluate novel targeted therapies (e.g. IL7R directed) with potential impact on outcome of adult T-ALL patients. This project was supported by the AECC (GC16173697BIGA); ISCIII (PI19/01828) co-funded by ERDF/ESF "A way to make Europe"/"Investing in your future", CERCA/Generalitat de Catalunya SGR 2017 288 (GRC)/ “La Caixa” P. Barba was supported by the Instituto de Salud Carlos III FIS16/01433 and PERIS 2018-2020 from Generalitat de Catalunya (BDNS357800). 2022-06-14T07:29:05Z 2022-06-14T07:29:05Z 2021-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Genescà E, Morgades M, González-Gil C, Fuster-Tormo F, Haferlach C, Meggendorfer M, et al. Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL). Leuk Res. 2021 Oct;109:106612. 0145-2126 https://hdl.handle.net/11351/7676 10.1016/j.leukres.2021.106612 34139642 000696732800016 http://hdl.handle.net/11351/7676 eng Leukemia Research;109 https://doi.org/10.1016/j.leukres.2021.106612 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf Elsevier Scientia