2026-04-13T11:31:25Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/76672025-10-24T10:29:02Zcom_2072_378070com_2072_378040col_2072_378092

Seizures after Ischemic Stroke: A Matched Multicenter Study Ferreira‑Atuesta, Carolina Döhler, Nico Erdélyi-Canavese, Barbara Felbecker, Ansgar Siebel, Philip Scherrer, Natalie Santamarina Pérez, Estevo Alvarez Sabin, José Abraira del Fresno, Laura Institut Català de la Salut [Ferreira-Atuesta C] Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, Queen Square, London, United Kingdom. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, United States. [Döhler N] Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland. Specialist Clinic for Neurorehabilitation, Kliniken Beelitz, Beelitz-Heilstätten, Germany. [Erdélyi-Canavese B, Felbecker A, Siebel P] Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland. [Scherrer N] Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland. [Abraira L, Santamarina E, Álvarez-Sabín J] Unitat d’Epilèpsia, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus Malalties cerebrovasculars - Complicacions Epilèpsia - Diagnòstic Convulsions - Diagnòstic DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Brain Ischemia Other subheadings::Other subheadings::Other subheadings::/complications DISEASES::Nervous System Diseases::Neurologic Manifestations::Seizures DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Epilepsy ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::isquemia cerebral Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::convulsiones ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::epilepsia Accidente cerebrovascular isquémico; Tratamiento de reperfusión; Factores de riesgo Ischemic Stroke; Reperfusion treatment; Risk factors Accident cerebrovascular isquèmic; Tractament de reperfusió; Factor de risc Objective The purpose of this study was to identify risk factors for acute symptomatic seizures and post-stroke epilepsy after acute ischemic stroke and evaluate the effects of reperfusion treatment. Methods We assessed the risk factors for post-stroke seizures using logistic or Cox regression in a multicenter study, including adults from 8 European referral centers with neuroimaging-confirmed ischemic stroke. We compared the risk of post-stroke seizures between participants with or without reperfusion treatment following propensity score matching to reduce confounding due to treatment selection. Results In the overall cohort of 4,229 participants (mean age 71 years, 57% men), a higher risk of acute symptomatic seizures was observed in those with more severe strokes, infarcts located in the posterior cerebral artery territory, and strokes caused by large-artery atherosclerosis. Strokes caused by small-vessel occlusion carried a small risk of acute symptomatic seizures. 6% developed post-stroke epilepsy. Risk factors for post-stroke epilepsy were acute symptomatic seizures, more severe strokes, infarcts involving the cerebral cortex, and strokes caused by large-artery atherosclerosis. Electroencephalography findings within 7 days of stroke onset were not independently associated with the risk of post-stroke epilepsy. There was no association between reperfusion treatments in general or only intravenous thrombolysis or mechanical thrombectomy with the time to post-stroke epilepsy or the risk of acute symptomatic seizures. Interpretation Post-stroke seizures are related to stroke severity, etiology, and location, whereas an early electroencephalogram was not predictive of epilepsy. We did not find an association of reperfusion treatment with risks of acute symptomatic seizures or post-stroke epilepsy. 2022-06-13T10:48:42Z 2022-06-13T10:48:42Z 2021-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ferreira-Atuesta C, Döhler N, Erdélyi-Canavese B, Felbecker A, Siebel P, Scherrer N, et al. Seizures after ischemic stroke: a matched multicenter study. Ann Neurol. 2021 Nov;90(5):808–20. 1531-8249 https://hdl.handle.net/11351/7667 10.1002/ana.26212 34505305 000701761000001 http://hdl.handle.net/11351/7667 eng Annals of Neurology;90(5) https://doi.org/10.1002/ana.26212 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf application/pdf Wiley Scientia