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oai:recercat.cat:11351/75722025-10-24T10:41:27Zcom_2072_378070com_2072_378040col_2072_378092

A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report Boistault, Margaux López-Corbeto, Mireia Quartier, Pierre Berbel Arcobé, Laura Carsi Durall, Ariadna Aeschlimann, Florence Institut Català de la Salut [Boistault M, Aeschlimann FA] Department of Pediatric Immunology-Hematology and Rheumatology, Necker University Hospital – Assitance Publique-Hopitaux de Paris, Paris, France. [Lopez Corbeto M] Unitat de Reumatologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Quartier P] Department of Pediatric Immunology-Hematology and Rheumatology, Necker University Hospital – Assitance Publique-Hopitaux de Paris, Paris, France. Université de Paris, Imagine Institute, Paris, France. [Berbel Arcobé L] Rheumatology Department, Mútua de Terrassa University Hospital, Terrassa, Spain. [Carsi Durall A] Unitat d’Urgències Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Infants Vasculitis - Tractament Anticossos monoclonals - Ús terapèutic DISEASES::Cardiovascular Diseases::Vascular Diseases::Vasculitis::Arteritis::Polyarteritis Nodosa Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal::Antibodies, Monoclonal, Humanized NAMED GROUPS::Persons::Age Groups::Child::Child, Preschool ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::vasculitis::arteritis::poliarteritis nudosa Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales::anticuerpos monoclonales humanizados DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño::niño preescolar Child; Polyarteritis nodosa; Tocilizumab Nena; Poliarteritis nodosa; Tocilizumab Niña; Poliarteritis nodosa; Tocilizumab Background Childhood Polyarteritis nodosa (PAN) is a systemic vasculitis with necrotizing inflammation of medium- and small-sized arteries. Disease evolution may be severe and refractory to standard treatment including prednisone, azathioprine and cyclophosphamide. Case presentation We present the case of a young girl with severe PAN resulting in progressive ischemia and necrosis of fingers and toes. Biological work-up revealed increased acute phase reactants and interleukin-6 levels. She was only partially controlled despite high-dose corticosteroids and cyclophosphamide infusions, and eventually achieved rapid improvement and sustained remission on tocilizumab. Further, we review the current evidence of the interleukin-6-inhibitor tocilizumab for the treatment of PAN. Conclusion Tocilizumab may be an efficient therapeutic option in a subset of treatment-refractory children with PAN. 2022-05-24T07:11:24Z 2022-05-24T07:11:24Z 2021-12-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Boistault M, Lopez Corbeto M, Quartier P, Berbel Arcobé L, Carsi Durall A, Aeschlimann FA. A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report. Pediatr Rheumatol. 2021 Dec 3;19:168. 1546-0096 https://hdl.handle.net/11351/7572 10.1186/s12969-021-00654-7 34861842 000726044400001 http://hdl.handle.net/11351/7572 eng Pediatric Rheumatology;19 https://doi.org/10.1186/s12969-021-00654-7 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf BMC Scientia