2026-04-17T17:02:01Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/75622024-06-06T13:36:56Zcom_2072_378071com_2072_378040col_2072_378097

NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond Rodríguez Sinovas, Antonio Corrales Insa, Irene Alonso Nieto, Judith Ballester-Servera, Carme Cañes Esteve, Laia Rodriguez, Cristina Martínez-González, José Institut Català de la Salut [Martínez-González J, Cañes L, Alonso J, Ballester-Servera C] Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), Barcelona, Spain. CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain. Instituto de Investigación Biomédica Sant Pau, Barcelona, Spain. [Rodríguez-Sinovas A] CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Corrales I] Laboratorio de Coagulopatías Congénitas, Banc de Sang i Teixits (BST), Barcelona, Spain. Grup de Recerca en Medicina Transfusional, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rodríguez C] CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain. Instituto de Investigación Biomédica Sant Pau, Barcelona, Spain. Institut de Recerca Hospital de la Santa Creu i Sant Pau (IRHSCSP), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Sistema cardiovascular - Malalties Sistema cardiovascular - Fisiologia Receptors cel·lulars DISEASES::Cardiovascular Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Receptors, Cytoplasmic and Nuclear PHENOMENA AND PROCESSES::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Vascular Remodeling ENFERMEDADES::enfermedades cardiovasculares COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::receptores citoplásmicos y nucleares FENÓMENOS Y PROCESOS::fenómenos fisiológicos respiratorios y circulatorios::fenómenos fisiológicos cardiovasculares::remodelación vascular Aneurisma aórtico abdominal; Aterosclerosis; Remodelación cardiovascular Aneurisma aòrtic abdominal; Aterosclerosi; Remodelació cardiovascular Abdominal aortic aneurysm; Atherosclerosis; Cardiovascular remodeling The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases. This research was funded by the Spanish Ministerio de Ciencia e Innovación (RTI2018-094727-B-100), Instituto de Salud Carlos III (ISCIII; PI18/0919 and PI20/01649), the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR; 2017-SGR-00333). The study was cofounded by Fondo Europeo de Desarrollo Regional (FEDER), a way to make Europe. C.B.-S. is supported by a FPU fellowship (Ministerio de Ciencia, Innovación y Universidades). 2022-05-20T10:37:28Z 2022-05-20T10:37:28Z 2021-10-21 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martínez-González J, Cañes L, Alonso J, Ballester-Servera C, Rodríguez-Sinovas A, Corrales I, et al. NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond. Int J Mol Sci. 2021 Oct 21;22(21):11371. 1422-0067 https://hdl.handle.net/11351/7562 10.3390/ijms222111371 34768801 000718535400001 eng International Journal of Molecular Sciences;22(21) https://doi.org/10.3390/ijms222111371 info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F01649 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI Scientia