2026-04-14T00:45:32Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/75582025-10-24T10:23:16Zcom_2072_451665com_2072_378040com_2072_378070col_2072_451666col_2072_378092

Higher mortality and intubation rate in COVID-19 patients treated with noninvasive ventilation compared with high-flow oxygen or CPAP Martí Beltran, Sergi Carsin, Anne-Elie Sampol Sirvent, Julia Pallero Castillo, Mercedes Aldás Criado, Irene Marin, Toni Tárrega, Julia Vélez Segovia, Eduardo Antonio Ferrer Sancho, Jaume [Marti S, Sampol J, Pallero M, Ferrer J] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. [Carsin AE] ISGlobal, Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Aldas I, Marin T] Respiratory Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. [Tárrega J] Respiratory Department, Hospital General de Granollers, Granollers, Spain. Universitat Internacional de Catalunya, Barcelona, Spain. [Vélez Segovia E] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Hospital General de Granollers COVID-19 (Malaltia) Insuficiència respiratòria Terapèutica DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections::Severe Acute Respiratory Syndrome ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Airway Management::Respiration, Artificial::Noninvasive Ventilation ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Airway Management::Intubation, Intratracheal DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus::síndrome respiratorio agudo grave TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::manejo de la via aérea::respiración artificial::ventilación no invasiva TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::manejo de la via aérea::intubación endotraqueal ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus COVID-19; Noninvasive ventilation; High-flow oxygen COVID-19; Ventilación no invasiva; Oxígeno de alto flujo COVID-19; Ventilació no invasiva; Oxigen d'alt cabal The effectiveness of noninvasive respiratory support in severe COVID-19 patients is still controversial. We aimed to compare the outcome of patients with COVID-19 pneumonia and hypoxemic respiratory failure treated with high-flow oxygen administered via nasal cannula (HFNC), continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV), initiated outside the intensive care unit (ICU) in 10 university hospitals in Catalonia, Spain. We recruited 367 consecutive patients aged ≥ 18 years who were treated with HFNC (155, 42.2%), CPAP (133, 36.2%) or NIV (79, 21.5%). The main outcome was intubation or death at 28 days after respiratory support initiation. After adjusting for relevant covariates and taking patients treated with HFNC as reference, treatment with NIV showed a higher risk of intubation or death (hazard ratio 2.01; 95% confidence interval 1.32-3.08), while treatment with CPAP did not show differences (0.97; 0.63-1.50). In the context of the pandemic and outside the intensive care unit setting, noninvasive ventilation for the treatment of moderate to severe hypoxemic acute respiratory failure secondary to COVID-19 resulted in higher mortality or intubation rate at 28 days than high-flow oxygen or CPAP. This finding may help physicians to choose the best noninvasive respiratory support treatment in these patients.Clinicaltrials.gov identifier: NCT04668196. 2022-05-20T09:59:28Z 2022-05-20T09:59:28Z 2022-04-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Marti S, Carsin AE, Sampol J, Pallero M, Aldas I, Marin T, et al. Higher mortality and intubation rate in COVID-19 patients treated with noninvasive ventilation compared with high-flow oxygen or CPAP. Sci Rep. 2022 Apr 20;12:6527. https://hdl.handle.net/11351/7558 10.1038/s41598-022-10475-7 35444251 http://hdl.handle.net/11351/7558 eng Scientific Reports;12 https://doi.org/10.1038/s41598-022-10475-7 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Nature Publishing Group Scientia