2026-04-14T02:49:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/74522025-10-24T10:35:02Zcom_2072_378070com_2072_378040col_2072_378092

Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes Soriano Marcolino, Milena Pires, Magda Carvalho Ferreira Ramos, Lucas Emanuel Tavares Silva, Rafael Guimarães‑Júnior, Milton Henriques Molina Romero, Israel Institut Català de la Salut [Molina I] PROSICS Barcelona. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Instituto René Rachou-FIOCRUZ Minas, 1715 Belo Horizonte, Brazil. [Marcolino MS] Department of Internal Medicine, Medical School and Telehealth Center, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil. [Pires MC, Ramos LEF, Silva RT] Department of Statistics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. [Guimarães-Júnior MH] Hospital Marcio Cunha, Ipatinga, Brazil Vall d'Hebron Barcelona Hospital Campus COVID-19 (Malaltia) - Complicacions Chagas, Malaltia de - Complicacions DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections Other subheadings::Other subheadings::Other subheadings::/complications ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de Chagas ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::mortalidad::mortalidad hospitalaria Epidemiología; Microbiología; SARS-CoV-2 Epidemiologia; Microbiologia; SARS-CoV-2 Epidemiology; Microbiology; SARS-CoV-2 Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64–80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation. This study was supported in part by Minas Gerais State Agency for Research and Development (Fundação de Amparo à Pesquisa do Estado de Minas Gerais—FAPEMIG) [Grant Number APQ-00208-20], National Institute of Science and Technology for Health Technology Assessment (Instituto de Avaliação de Tecnologias em Saúde—IATS)/National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq) [Grant Number 465518/2014-1], and CAPES Foundation (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) [Grant Number 88887.507149/2020-00]. 2022-05-02T13:12:52Z 2022-05-02T13:12:52Z 2021-10-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Molina I, Marcolino MS, Pires MC, Ramos LEF, Silva RT, Guimarães-Júnior MH, et al. Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes. Sci Rep. 2021 Oct 13;11:20289. 2045-2322 https://hdl.handle.net/11351/7452 10.1038/s41598-021-96825-3 34645833 000707032500018 http://hdl.handle.net/11351/7452 eng Scientific Reports;11 https://doi.org/10.1038/s41598-021-96825-3 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf Nature Research Scientia