2026-04-17T04:31:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/73892024-11-22T07:54:39Zcom_2072_378070com_2072_378040col_2072_378092

Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis Doulaptsi, Maria Wils, Tine Hellings, Peter W. Martens, Katleen Farré, Ricard Vicario Perez, Maria Rinitis - Tractament Cèl·lules epitelials Medicaments - Efectes fisiològics DISEASES::Respiratory Tract Diseases::Nose Diseases::Rhinitis::Rhinitis, Allergic Other subheadings::Other subheadings::Other subheadings::/drug therapy ANATOMY::Cells::Epithelial Cells Other subheadings::Other subheadings::/drug effects ENFERMEDADES::enfermedades respiratorias::enfermedades nasales::rinitis::rinitis alérgica Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia ANATOMÍA::células::células epiteliales Otros calificadores::Otros calificadores::/efectos de los fármacos Rinitis alérgica; Integridad epitelial; Furoato de mometasona Rinitis al·lèrgica; Integritat epitelial; Furoat de mometasona Allergic rhinitis; Epithelial integrity; Mometasone furoate Tight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on TJs and by reducing type 2 cytokine production. However, the effect of different classes of intranasal corticosteroids on the epithelial barrier has not been studied. Therefore, we compared the effect of 2 intranasal corticosteroids, ie, fluticasone furoate (FF) and mometasone furoate (MF) on epithelial barrier function. Both FF and MF similarly increased trans-epithelial electrical resistance of primary nasal epithelial cell cultures from AR patients. In a house dust mite-induced allergic asthma mouse model, FF and MF had similar beneficial effects on fluorescein isothiocyanate–dextran 4 kDa mucosal permeability, eosinophilic infiltration and IL-13 levels. Both molecules increased mRNA expression of the TJ proteins occludin and zonula occludens-1, thereby restoring epithelial barrier function. Lastly, we showed that long-term FF treatment also increased expression of occludin in AR patients compared to controls. In conclusion, both FF and MF effectively restore epithelial barrier function by increasing expression of TJ proteins in AR patients. This work was supported by an unrestricted grant from GSK. BS is supported by the Fund for Scientific Research Flanders (FWO), Belgium. 2022-04-25T10:04:38Z 2022-04-25T10:04:38Z 2021-09-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion World Allergy Organization Journal;14(9) https://doi.org/10.1016/j.waojou.2021.100585 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Elsevier Scientia