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Etiologies and 12-month mortality in patients with isolated involuntary weight loss at a rapid diagnostic unit Aligué, Jordi Vicente, Mireia Arnau, Anna Trapé, Jaume Martínez, Eva Bonet, Mariona San Jose Laporte, Antonio Institut Català de la Salut [Aligué J] Central Catalonia Chronicity Research Group (C3RG), Internal Medicine Department, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain. Faculty of Medicine, University of Vic—Central University of Catalonia (UVIC-UCC), Vic, Spain. [Vicente M] Primary Care, Institut Català de la Salut, Barcelona, Spain. [Arnau A] Central Catalonia Chronicity Research Group (C3RG), Clinical Research Unit. Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain. [Trapé J] Faculty of Medicine, University of Vic—Central University of Catalonia (UVIC-UCC), Vic, Spain. Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain. [Martínez E, Bonet M] Internal Medicine Department, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain. [San José A] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus Càncer - Diagnòstic Aprimament Mortalitat DISEASES::Neoplasms Other subheadings::Other subheadings::/diagnosis DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Body Weight Changes::Weight Loss ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality ENFERMEDADES::neoplasias Otros calificadores::Otros calificadores::/diagnóstico ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::cambios en el peso corporal::pérdida de peso TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::mortalidad Detección y diagnóstico del cáncer; Tumores malignos; Etiología Detecció i diagnòstic del càncer; Tumors malignes; Etiologia Cancer detection and diagnosis; Malignant tumors; Etiology Background Numerous studies on involuntary weight loss (IWL) have been published since the 1980s, although most of them have included small samples of patients with specific symptoms. The aim of the present study was to determine the causes, demographic and clinical characteristics and mortality at 12 months in patients attended at a rapid diagnostic unit (RDU) for isolated IWL. Methods A single-center retrospective observational study including all patients presenting to the RDU for isolated IWL between 2005 and 2013. The following data were recorded: demographic and clinical variables, results of complementary tests (blood tests, x-rays, computed tomography scan and digestive endoscopy), main diagnosis and vital status at 12 months. Results Seven hundred and ninety-one patients met the criteria for IWL. Mean age was 67.9 years (SD 4.7), 50.4% were male and mean weight loss was 8.3 kg (SD 4.7). The cause for IWL was malignant disease in 23.6% of patients, non-malignant organic disease in 44.5%, psychiatric disorder in 29.0% and unknown in 3.2%. Overall mortality at 12 months was 18.6% (95%CI: 16.1–21.6). The mortality rate was highest in the group with malignancy (61.1%; 95%CI: 54.2–68.2). Conclusions Almost a quarter of all patients attended at the RDU for IWL were diagnosed with cancer. Mortality at 12 months was higher in this group than in the other three. Malignancy should therefore be ruled out during the first visit for patients attended for IWL. The authors received no specific funding for this work. 2022-04-22T15:40:06Z 2022-04-22T15:40:06Z 2021-09-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Aligué J, Vicente M, Arnau A, Trapé J, Martínez E, Bonet M, et al. Etiologies and 12-month mortality in patients with isolated involuntary weight loss at a rapid diagnostic unit. PLoS One. 2021 Sep 23;16(9):e0257752. 1932-6203 https://hdl.handle.net/11351/7387 10.1371/journal.pone.0257752 34555091 000725694500065 http://hdl.handle.net/11351/7387 eng PLOS ONE;16(9) https://doi.org/10.1371/journal.pone.0257752 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf Public Library of Science Scientia