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Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction Inserte Igual, Javier Barrabés Riu, José Antonio Aluja Gonzalez, David Bañeras Rius, Jordi Sánchez Sánchez, Ana Mila Pascual, Laia Lidón Corbi, Rosa María De Carvalho Negrao Valente, Filipa Xavier Rafecas Ventosa, Agnès Rodríguez Sinovas, Antonio Benito Villabriga, Begoña Buera Surribas, Irene Ferreira González, Ignacio Beneitez Pastor, David Ruiz Meana, Marisol Miro Casas, Elisabet Rodríguez Palomares, Jose Fernando Sambola Ayala, Antonia Castellote Bellés, Laura Delgado Tomás, Sara Otaegui Irurueta, Imanol Institut Català de la Salut [Inserte J, Barrabés JA, Aluja D, Otaegui I, Bañeras J, Sánchez A, Rodríguez-Palomares JF, Miró-Casas E, Milà L, Lidón RM, Sambola A, Valente F, Rafecas A, Ruiz-Meana M, Rodríguez-Sinovas A, Benito B, Buera I, Delgado-Tomás S, Ferreira-González I] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Castellote L] Servei de Bioquímica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Beneítez D] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Infart de miocardi - Imatgeria Malalties coronàries - Cirurgia - Complicacions Dèficit de ferro DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Anemia::Anemia, Hypochromic::Anemia, Iron-Deficiency DISEASES::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Myocardial Infarction ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Surgical Procedures, Operative::Minimally Invasive Surgical Procedures::Endovascular Procedures::Percutaneous Coronary Intervention Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::anemia::anemia hipocrómica::anemia ferropénica ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::infarto de miocardio TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::intervenciones quirúrgicas::procedimientos quirúrgicos mínimamente invasivos::procedimientos endovasculares::cirugía coronaria percutánea Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos Infarto agudo de miocardio; Sintasa; Deficiencia de hierro Infart agut de miocardi; Sintasa; Deficiència de ferro Acute myocardial infarction; Synthase; Iron deficiency In patients with a first anterior ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention, iron deficiency (ID) was associated with larger infarcts, more extensive microvascular obstruction, and higher frequency of adverse left ventricular remodeling as assessed by cardiac magnetic resonance imaging. In mice, an ID diet reduced the activity of the endothelial nitric oxide synthase/soluble guanylate cyclase/protein kinase G pathway in association with oxidative/nitrosative stress and increased infarct size after transient coronary occlusion. Iron supplementation or administration of an sGC activator before ischemia prevented the effects of the ID diet in mice. Not only iron excess, but also ID, may have deleterious effects in the setting of ischemia and reperfusion. This study was funded by Instituto de Salud Carlos III, Spain, through the project PI16/00232 and the research network CIBERCV (CB16/11/00479), both cofunded by European Regional Development Fund, and by the Sociedad Española de Cardiología (Proyecto de Investigación Traslacional en Cardiología 2016). The authors have reported that they have no relationships relevant to the contents of this paper to disclose. 2022-04-22T12:48:39Z 2022-04-22T12:48:39Z 2021-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Inserte J, Barrabés JA, Aluja D, Otaegui I, Bañeras J, Castellote L, et al. Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction. JACC Basic to Transl Sci. 2021 Jul;6(7):567–80. 2452-302X https://hdl.handle.net/11351/7370 10.1016/j.jacbts.2021.05.004 34368505 000677976700001 eng JACC: Basic to Translational Science;6(7) https://doi.org/10.1016/j.jacbts.2021.05.004 info:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F00232 info:eu-repo/grantAgreement/ES/PE2013-2016/CB16%2F11%2F00479 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf Elsevier Scientia