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Milk and cow’s meat allergy in a child: A clinical case Marques, Maria Luís Falcão, Inês Labrador Horrillo, Moisés Falcão, Helena Cunha, Leonor Institut Català de la Salut [Marques ML, Falcão I, Falcão H, Cunha L] Allergy and Clinical Immunology Department. Hospital Geral de Santo António, Centro Hospitalar Universitário do Porto, Porto, Portugal. [Labrador-Horrillo M] Secció d’Al·lèrgia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus Al·lèrgia alimentària - Diagnòstic Infants DISEASES::Immune System Diseases::Hypersensitivity::Hypersensitivity, Immediate::Food Hypersensitivity Other subheadings::Other subheadings::/diagnosis NAMED GROUPS::Persons::Age Groups::Child::Child, Preschool ENFERMEDADES::enfermedades del sistema inmune::hipersensibilidad::hipersensibilidad inmediata::hipersensibilidad a los alimentos Otros calificadores::Otros calificadores::/diagnóstico DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño::niño preescolar Albúmina sèrica bovina; Al·lèrgia alimentària; Al·lèrgia a la carn Albúmina sérica bovina; Alergia a la comida; Alergia a la carne Bovine serum albumin; Food allergy; Meat allergy Allergy to bovine serum albumin is the main predictor of beef allergy associated with cow’s milk proteins allergy. We report a case of a 3-year-old child with cow’s milk proteins allergy since the age of 6 months who, after some ingestions of beef, developed episodes of irritability, urticaria and syncope. Specific IgE to beef, oral food challenge with medium rare cooked beef and specific IgE to bovine serum albumin were all positive, but an oral food challenge with well cooked beef was tolerated. Allergy to bovine serum albumin is not usually associated with severe reactions, since it is a thermolabile protein, however, the process of cooking meat may be insufficient to have an effect on the complex matrix of meat and associated serum albumins. The irregular pattern of the episodes and the previous diagnosis of cow’s milk proteins allergy may act as confounding factos leading to a delayed diagnosis. 2022-04-06T07:19:11Z 2022-04-06T07:19:11Z 2021-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Marques ML, Falcão I, Labrador-Horrillo M, Falcão H, Cunha L. Milk and cow’s meat allergy in a child: A clinical case. Rev Port Imunoalergologia. 2021 Dec;29(4):273–7. 0871-9721 https://hdl.handle.net/11351/7310 10.32932/rpia.2021.12.072 http://hdl.handle.net/11351/7310 eng Revista Portuguesa de Imunoalergologia;29(4) https://doi.org/10.32932/rpia.2021.12.072 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf Publicações Ciência & Vida Scientia