2026-04-14T06:47:32Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/71762025-10-24T11:00:03Zcom_2072_451665com_2072_378040col_2072_451666

Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu Baston Rey, Iria Garcia Garcia, Maria Jose Rivero, Montserrat Miranda-Bautista, Jose Mesonero, Francisco Leo-Carnerero, Eduardo Delgado Guillena, Pedro Genaro [García MJ, Rivero M] Gastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Santander, Spain. [Miranda-Bautista J] Gastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, Madrid, Spain. [Bastón-Rey I] Gastroenterology Department, Hospital Universitario Clínico de Santiago, Santiago de Compostela, Spain. [Mesonero F] Gastroenterology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Leo-Carnerero E] Gastroenterology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Delgado-Guillena P] Gastroenterology Department, Hospital General de Granollers, Granollers, Spain Hospital General de Granollers Crohn, Malaltia de Productes biològics Cirurgia - Complicacions DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Disease DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Postoperative Complications CHEMICALS AND DRUGS::Complex Mixtures::Biological Products ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal::enfermedad de Crohn ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::complicaciones posoperatorias COMPUESTOS QUÍMICOS Y DROGAS::mezclas complejas::productos biológicos Enfermedad de Crohn; Cirugía; Complicaciones postoperatorias Malaltia de Crohn; Cirurgia; Complicacions postoperatòries Crohn’s disease; Surgery; Postoperative complications Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered "exposed". The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2-2.0), urgent surgery (OR: 1.6; 95% CI: 1.2-2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1-1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3-2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97-1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03-2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections. 2022-03-15T07:31:34Z 2022-03-15T07:31:34Z 2021-09-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion García MJ, Rivero M, Miranda-Bautista J, Bastón-Rey I, Mesonero F, Leo-Carnerero E, et al. Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu. J Clin Med. 2021 Sep 26;10(19):4402. 2077-0383 https://hdl.handle.net/11351/7176 10.3390/jcm10194402 34640421 http://hdl.handle.net/11351/7176 eng Journal of Clinical Medicine;10(19) https://doi.org/10.3390/jcm10194402 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI Scientia