2026-04-13T18:23:04Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/70502024-12-13T10:17:30Zcom_2072_378071com_2072_378040col_2072_378097

00925njm 22002777a 4500 dc Scarsoglio, Stefania author Ridolfi, Luca author Guala, Andrea author Calò, Karol author Gallo, Diego author Rodríguez Palomares, Jose Fernando author 2022-02-22T07:22:00Z 2022-02-22T07:22:00Z 2021-09 Dilatació aòrtica; Aneurisma de l'aorta ascendent; Anàlisi espai-temporal Dilatación aórtica; Aneurisma de la aorta ascendente; Análisis espacio-temporal Aortic dilation; Ascending aorta aneurysm; Spatiotemporal analysis Motivated by the evidence that the onset and progression of the aneurysm of the ascending aorta (AAo) is intertwined with an adverse hemodynamic environment, the present study characterized in vivo the hemodynamic spatiotemporal complexity and organization in human aortas, with and without dilated AAo, exploring the relations with clinically relevant hemodynamic and geometric parameters. The Complex Networks (CNs) theory was applied for the first time to 4D flow magnetic resonance imaging (MRI) velocity data of ten patients, five of them presenting with AAo dilation. The time-histories along the cardiac cycle of velocity-based quantities were used to build correlation-based CNs. The CNs approach succeeded in capturing large-scale coherent flow features, delimiting flow separation and recirculation regions. CNs metrics highlighted that an increasing AAo dilation (expressed in terms of the ratio between the maximum AAo and aortic root diameter) disrupts the correlation in forward flow reducing the correlation persistence length, while preserving the spatiotemporal homogeneity of secondary flows. The application of CNs to in vivo 4D MRI data holds promise for a mechanistic understanding of the spatiotemporal complexity and organization of aortic flows, opening possibilities for the integration of in vivo quantitative hemodynamic information into risk stratification and classification criteria. Open access funding provided by Politecnico di Torino within the CRUI-CARE Agreement. http://hdl.handle.net/11351/7050 Aorta - Imatgeria Imatgeria per al diagnòstic Hemodinàmica PHENOMENA AND PROCESSES::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging ANATOMY::Cardiovascular System::Blood Vessels::Arteries::Aorta Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging FENÓMENOS Y PROCESOS::fenómenos fisiológicos respiratorios y circulatorios::fenómenos fisiológicos cardiovasculares::hemodinámica TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética ANATOMÍA::sistema cardiovascular::vasos sanguíneos::arterias::aorta Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen Combining 4D Flow MRI and Complex Networks Theory to Characterize the Hemodynamic Heterogeneity in Dilated and Non-dilated Human Ascending Aortas