2026-04-17T06:50:46Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/69912025-10-24T07:50:27Zcom_2072_451669com_2072_378040col_2072_451670

00925njm 22002777a 4500 dc Louro, Javier author Román, Marta author Posso, Margarita author Comerma Blesa, Laura author Saladie, Francina author Alcantara-Souza, Rodrigo author Sánchez, Mar author Quintana, María Jesús author del Riego, Javier author Ferrer, Joana author Vidal, Carmen author 2022-02-08T14:32:17Z 2022-02-08T14:32:17Z 2020-10-03 Neoplàsies de mama; Detecció precoç del càncer; Factors de risc Neoplasias de mama; Detección precoz del cáncer; Factores de riesgo Breast neoplasms; Early cancer detection; Risk factors Introduction: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. Materials and methods: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or roliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. Results: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value ¼ 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24e3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57e2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09e9.08, and 3.35; 95%CI: 1.51e7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95e2.93, and 1.63; 95%CI: 1.32e2.02 for those diagnosed at incident and prevalent screens, respectively). Conclusion: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis This study was supported by grants from Instituto de Salud Carlos III FEDER (grant numbers: PI15/00098 and PI17/00047), and by the Research Network on Health Services in Chronic Diseases (RD12/0001/0015) http://hdl.handle.net/11351/6991 Mama - Càncer - Diagnòstic Mama - Càncer - Factors de risc Mama - Malalties - Imatgeria DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Breast Diseases::Breast Neoplasms ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography::Mammography ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades de la mama::neoplasias de la mama TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::radiografía::mamografía TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo Differences in breast cancer risk after benign breast disease by type of screening diagnosis