2026-04-17T05:43:41Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/69192025-10-24T10:56:14Zcom_2072_451667com_2072_378040col_2072_451668

Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women Cruz-Lemini, Mónica Ferriols Pérez, Elena de la Cruz, María Luisa Caño Aguilar, Africa Encinas Pardilla, Maria Begoña Prats, P Rodríguez, Agueda COVID-19 (Malaltia) Embaràs DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproduction::Pregnancy DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Asymptomatic Diseases::Asymptomatic Infections ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::reproducción::embarazo ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedades asintomáticas::infecciones asintomáticas Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Embaràs; Infecció asimptomàtica Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Embarazo; Infección asintomática Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Pregnancy; Asymptomatic infection Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms. This project was supported by public funds obtained in competitive calls: Grant COV20/00021 (EUR 43,000 from the Instituto de Salud Carlos III—Spanish Ministry of Health and co-financed with Fondo Europeo de Desarrollo Regional (FEDER) funds. Dr Cruz-Lemini is supported by a Juan Rodés contract JR19/00047, Instituto de Salud Carlos III—Spanish Ministry of Health. The funding bodies had no role in the study design, in the collection or analysis of the data, or in manuscript writing. 2025-10-24T10:56:14Z 2025-10-24T10:56:14Z 2025-10-24T10:56:14Z 2022-01-27T13:07:24Z 2022-01-27T13:07:24Z 2021-01-15 info:eu-repo/semantics/article http://hdl.handle.net/11351/6919 Viruses;13(1) https://doi.org/10.3390/v13010112 Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess MDPI Scientia