2026-04-17T04:16:40Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/69072025-10-24T10:28:28Zcom_2072_378070com_2072_378040com_2072_451669col_2072_378092col_2072_451670

Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up de Deus Fonticoba, Teresa Cores Bartolomé, Carlos Canfield, Hector Aguilar, Miquel Cosgaya, Marina Ávila Rivera, María A. Nogueira, Víctor Solano Vila, Berta Cubo, Esther Carrillo Padilla, Francisco Martinez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, Maria G. López-Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Blázquez Estrada, Marta Seijo, Manuel Ruiz-Martinez, Javier Valero, Caridad Kurtis, Mónica de Fabregues-Boixar Nebot, Oriol González Ardura, Jessica Alonso Redondo, Ruben Ordás, Carlos López Díaz, Luis M. McAfee, Darrian Martinez-Martin, Pablo Mir, Pablo Garcia-Caldentey, Juan Legarda, Ines Cabo López, Iria Gonzalez-Aramburu, Isabel Gómez-Mayordomo, Víctor Pastor, Pau Lopez Manzanares, Lydia Puente, Victor Dotor, Julio borrue fernandez, carmen Alvarez Sauco, Maria Vela-Desojo, Lydia Escalante Arroyo, Sonia JESUS MAESTRE, SILVIA HERNANDEZ-VARA, JORGE Naya Ríos, Lucía García Roca, Lucía Feal, María Santos García, Diego MARTINEZ MIRO, CRISTINA Caballol, Nuria Parkinson, Malaltia de Fenotip Tremolor DISEASES::Nervous System Diseases::Central Nervous System Diseases::Nervous System Diseases::Central Nervous System Diseases::Movement Disorders::Parkinsonian Disorders::Nervous System Diseases::Parkinson Disease PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Dyskinesias::Tremor ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::trastornos del movimiento::trastornos parkinsonianos::enfermedades del sistema nervioso::enfermedad de Parkinson FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::discinesias::temblor Malaltia de Parkinson; Fenotip; Tremolor Enfermedad de Parkinson; Fenotipo; Temblor Parkinson’s disease; Phenotype; Tremor Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity. Solano Vila B. has received honoraria for educational presentations and advice service by UCB, Zambon, Teva, Abbvie, Bial 2025-10-24T10:28:28Z 2025-10-24T10:28:28Z 2025-10-24T10:28:28Z 2022-01-26T12:02:41Z 2022-01-26T12:02:41Z 2021-12-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/6907 Diagnostics;11(12) https://doi.org/10.3390/diagnostics11122380 Attribution-ShareAlike 4.0 International http://creativecommons.org/licenses/by-sa/4.0/ info:eu-repo/semantics/openAccess MDPI Scientia