2026-04-17T06:34:14Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/69072025-10-24T10:28:28Zcom_2072_378070com_2072_378040com_2072_451669col_2072_378092col_2072_451670

00925njm 22002777a 4500 dc de Deus Fonticoba, Teresa author Cores Bartolomé, Carlos author Canfield, Hector author Aguilar, Miquel author Cosgaya, Marina author Ávila Rivera, María A. author Nogueira, Víctor author Solano Vila, Berta author Cubo, Esther author Carrillo Padilla, Francisco author Martinez Castrillo, Juan Carlos author Sánchez Alonso, Pilar author Alonso Losada, Maria G. author López-Ariztegui, Nuria author Gastón, Itziar author Kulisevsky, Jaime author Blázquez Estrada, Marta author Seijo, Manuel author Ruiz-Martinez, Javier author Valero, Caridad author Kurtis, Mónica author de Fabregues-Boixar Nebot, Oriol author González Ardura, Jessica author Alonso Redondo, Ruben author Ordás, Carlos author López Díaz, Luis M. author McAfee, Darrian author Martinez-Martin, Pablo author Mir, Pablo author Garcia-Caldentey, Juan author Legarda, Ines author Cabo López, Iria author Gonzalez-Aramburu, Isabel author Gómez-Mayordomo, Víctor author Pastor, Pau author Lopez Manzanares, Lydia author Puente, Victor author Dotor, Julio author borrue fernandez, carmen author Alvarez Sauco, Maria author Vela-Desojo, Lydia author Escalante Arroyo, Sonia author JESUS MAESTRE, SILVIA author HERNANDEZ-VARA, JORGE author Naya Ríos, Lucía author García Roca, Lucía author Feal, María author Santos García, Diego author MARTINEZ MIRO, CRISTINA author Caballol, Nuria author 2022-01-26T12:02:41Z 2022-01-26T12:02:41Z 2021-12-17 Malaltia de Parkinson; Fenotip; Tremolor Enfermedad de Parkinson; Fenotipo; Temblor Parkinson’s disease; Phenotype; Tremor Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity. Solano Vila B. has received honoraria for educational presentations and advice service by UCB, Zambon, Teva, Abbvie, Bial http://hdl.handle.net/11351/6907 Parkinson, Malaltia de Fenotip Tremolor DISEASES::Nervous System Diseases::Central Nervous System Diseases::Nervous System Diseases::Central Nervous System Diseases::Movement Disorders::Parkinsonian Disorders::Nervous System Diseases::Parkinson Disease PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Dyskinesias::Tremor ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::trastornos del movimiento::trastornos parkinsonianos::enfermedades del sistema nervioso::enfermedad de Parkinson FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::discinesias::temblor Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up