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Chronic hepatitis D associated with worse patient-reported outcomes than chronic hepatitis B Stepanova, Maria Palom Agusti, Adriana Riveiro Barciela, Maria del Mar Nader, Fatema Roade Tato, Maria Luisa Esteban Mur, Rafael Younossi, Zobair M. Buti Ferret, Maria Institut Català de la Salut [Buti M, Riveiro-Barciela M, Roade L, Esteban R] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Stepanova M, Nader F] Center for Outcomes Research in Liver Disease, Washington, DC, USA. [Palom A] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Younossi Z] Department of Medicine, Center for Liver Diseases, Inova Fairfax, Hospital, Falls Church, VA, USA. Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA Vall d'Hebron Barcelona Hospital Campus Hepatitis vírica - Diagnòstic Cirrosi hepàtica Avaluació de resultats (Assistència sanitària) DISEASES::Digestive System Diseases::Liver Diseases::Hepatitis::Hepatitis, Viral, Human::Hepatitis D Other subheadings::Other subheadings::/diagnosis DISEASES::Digestive System Diseases::Liver Diseases::Liver Cirrhosis HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Outcome and Process Assessment (Health Care) ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hepatitis::hepatitis viral humana::hepatitis D Otros calificadores::Otros calificadores::/diagnóstico ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::cirrosis hepática ATENCIÓN DE SALUD::administración de los servicios de salud::calidad de la atención sanitaria::evaluación de resultados y procesos (atención a la salud) Hepatitis vírica; Qualitat de vida relacionada amb la salut; Malaltia hepàtica crònica Hepatitis viral; Calidad de vida relacionada con la salud; Enfermedad crónica del hígado Viral hepatitis; Health-related quality of life; Chronic Liver Disease Background & Aims Health-related quality of life (HRQoL) determined by patient-reported outcomes (PROs) is impaired in chronic hepatitis B (CHB) and C patients, but there are no data regarding patients with chronic hepatitis D (CHD). The aim of this study was to assess PRO scores in untreated patients with CHD and compare them with those obtained for patients with CHB. Methods Patients with CHD completed 3 PRO instruments (Chronic Liver Disease Questionnaire [CLDQ], Functional Assessment of Chronic Illness Therapy–Fatigue [FACIT-F], and Work Productivity and Activity Impairment [WPAI]), and the results were compared with those of patients mono-infected with CHB. Results In total, 125 patients were included: 43 with CHD and 82 with CHB. Overall, baseline PROs showed differences between both groups. Several assessments, such as the worry score from CLDQ (p = 0.0118), functional well-being from FACIT-F (p = 0.0281), and activity impairment from WPAI (p = 0.0029) showed a significant trend to worse scores in patients with CHD than with CHB. In addition, the linear regression model supports the finding that having CHD as opposed to having CHB was a predictor of a higher worry score (CLDQ) and a higher activity impairment (WPAI). Conclusions In this first assessment in CHD, PROs recorded in patients with CHD showed a significant impairment in some domains of HRQoL questionnaires in comparison with those with CHB. Studies in larger cohorts with lengthier follow-up are needed to fully assess patient-reported quality of life over the course of CHD. Lay summary Chronic hepatitis D (CHD) is a viral disease that causes rapid evolution to liver cirrhosis, amongst other severe complications, when compared to patients with chronic hepatitis B (CHB). Health-related quality of life in chronic hepatitis C and CHB has been reported widely, but no studies have been performed on patient-reported outcomes in patients with CHD. Results showed that CHD patients reported worse outcomes in psychological domains such as worry and emotional well-being, as well as in physical domains such as abdominal symptoms, physical well-being, and activity impairment in comparison with patients with CHB. 2022-01-13T14:14:48Z 2022-01-13T14:14:48Z 2021-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Buti M, Stepanova M, Palom A, Riveiro-Barciela M, Nader F, Roade L, et al. Chronic hepatitis D associated with worse patient-reported outcomes than chronic hepatitis B. JHEP Reports. 2021 Jun;3:100280. 2589-5559 https://hdl.handle.net/11351/6787 10.1016/j.jhepr.2021.100280 34041466 000658290100019 http://hdl.handle.net/11351/6787 eng JHEP reports;3 https://doi.org/10.1016/j.jhepr.2021.100280 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf application/pdf application/pdf Elsevier Scientia