2026-04-19T19:19:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/66272025-10-24T10:15:41Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Carbonell, Raquel author Moreno, Gerard author Martin-Loeches, Ignacio author Gomez-Bertomeu, Frederic author Sarvisé, Carolina author Gómez, Josep author Papiol Gallofré, Elisabeth author 2021-11-30T13:27:51Z 2021-11-30T13:27:51Z 2021-03-26 Proteïna C-reactiva; Pneumònia; Procalcitonina Proteína C-reactiva; Neumonía; Procalcitonina C-Reactive protein; Pneumonia; Procalcitonin Background: Procalcitonin (PCT) and C-Reactive protein (CRP) are well-established sepsis biomarkers. The association of baseline PCT levels and mortality in pneumonia remains unclear, and we still do not know whether biomarkers levels could be related to the causative microorganism (GPC, GNB). The objective of this study is to address these issues. Methods: a retrospective observational cohort study was conducted in 184 Spanish ICUs (2009–2018). Results: 1608 patients with severe influenza pneumonia with PCT and CRP available levels on admission were included, 1186 with primary viral pneumonia (PVP) and 422 with bacterial Co-infection (BC). Those with BC presented higher PCT levels (4.25 [0.6–19.5] versus 0.6 [0.2–2.3]ng/mL) and CRP (36.7 [20.23–118] versus 28.05 [13.3–109]mg/dL) as compared to PVP (p < 0.001). Deceased patients had higher PCT (ng/mL) when compared with survivors, in PVP (0.82 [0.3–2.8]) versus 0.53 [0.19–2.1], p = 0.001) and BC (6.9 [0.93–28.5] versus 3.8 [0.5–17.37], p = 0.039). However, no significant association with mortality was observed in the multivariate analysis. The PCT levels (ng/mL) were significantly higher in polymicrobial infection (8.4) and GPC (6.9) when compared with GNB (1.2) and Aspergillus (1.7). The AUC-ROC of PCT for GPC was 0.67 and 0.32 for GNB. The AUROC of CRP was 0.56 for GPC and 0.39 for GNB. Conclusions: a single PCT/CRP value at ICU admission was not associated with mortality in severe influenza pneumonia. None of the biomarkers have enough discriminatory power to be used for predicting the causative microorganism of the co-infection. This research received no external funding. This study was supported by the Spanish Intensive Care Society (SEMICYUC) and Ricardo Barri Casanovas Foundation (Alejandro Rodríguez). The study sponsors have no role in the study design, data collection, data analysis, data interpretation, or writing of the report. http://hdl.handle.net/11351/6627 Pneumònia Marcadors bioquímics Prognosi DISEASES::Respiratory Tract Diseases::Lung Diseases::Pneumonia CHEMICALS AND DRUGS::Biological Factors::Biomarkers ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::neumonía COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico Prognostic Value of Procalcitonin and C-Reactive Protein in 1608 Critically Ill Patients with Severe Influenza Pneumonia