2026-04-17T08:10:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/65662024-12-13T10:20:07Zcom_2072_378071com_2072_378040col_2072_378097

Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus Gazeta, Rosa Estela Bertozzi, Ana Paula Antunes Pascalicchio Dezena, Rita de Cássia de Aguirre Bernardes Silva, Andrea Cristina Botelho Fajardo, Thamirys Cosmo Gillo Catalan, Daniel T. Soriano Arandes, Antoni Institut Català de la Salut [Gazeta RE, Bertozzi APAP] Pediatrics Department, Jundiaí Medical School, Jundiaí 13202-550, Brazil. [Dezena RCAB] University Center Campo Limpo Paulista-UNIFACCAMP, Campo Limpo Paulista, São Paulo 13231-230, Brazil. [Silva ACB, Fajardo TCG, Catalan DT] . Pediatric Infectology Laboratory, Jundiaí Medical School, Jundiaí 13202-550, Brazil. [Soriano-Arandes A] Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus Arbovirosis Infants Embaràs - Complicacions DISEASES::Virus Diseases::Arbovirus Infections::Zika Virus Infection DISEASES::Bacterial Infections and Mycoses::Infection::Pregnancy Complications, Infectious NAMED GROUPS::Persons::Age Groups::Child::Child, Preschool ENFERMEDADES::virosis::infecciones por arbovirus::infección por el virus del Zika ENFERMEDADES::infecciones bacterianas y micosis::infección::complicaciones infecciosas del embarazo DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño::niño preescolar Virus del Zika, Infecció congènita; Mcrocefàlia Virus del Zika; Infección congénita; Microcefalia Zika virus; Congenital infection; Microcephaly Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, may have a later onset. We conducted a prospective cohort study of 799 high-risk pregnant women who were followed up until delivery. Eighty-three women and/or newborns were considered ZIKV exposed and/or infected. Laboratory diagnosis was made by polymerase chain reaction in the pregnant mothers and their respective newborns, as well as Dengue virus, Chikungunya virus, and ZIKV serology. Serology for toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, and syphilis infections were also performed in microcephalic newborns. The newborns included in the study were followed up until their third birthday. Developmental delay was observed in nine patients (13.2%): mild cognitive delay in three patients, speech delay in three patients, autism spectrum disorder in two patients, and severe neurological abnormalities in one microcephalic patient; sensorineural hearing loss, three patients and dysphagia, six patients. Microcephaly due to ZIKV occurred in three patients (3.6%). Clinical manifestations can appear after the first year of life in children infected/exposed to ZIKV, emphasizing the need for long-term follow-up. This paper was financed by FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) (SDP# 2016/8578-0 DFV 2014/26818-2), CNPq Brazilian National Research Council (DFV 309409/2015-2); Brazilian Ministry of Health (SDP #861306/2017) and London School of Hygiene and Tropical Medicine (SDP # grantPC0002/16). 2021-11-19T08:42:19Z 2021-11-19T08:42:19Z 2021-03-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gazeta RE, Bertozzi APAP, Dezena RCAB, Silva ACB, Fajardo TCG, Catalan DT, et al. Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus. Viruses. 2021 Mar 22;13:523. 1999-4915 https://hdl.handle.net/11351/6566 10.3390/v13030523 33810110 000634247700001 http://hdl.handle.net/11351/6566 eng Viruses;13 https://doi.org/10.3390/v13030523 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf application/pdf application/pdf application/pdf MDPI Scientia