2026-04-13T02:18:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/61922025-11-08T15:59:21Zcom_2072_378070com_2072_378040col_2072_378092

Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage Fernández de Gamarra‑Oca, Lexuri Zubiaurre‑Elorza, Leire Junqué, Carme Solana, Elisabeth Soria‑Pastor, Sara Vázquez Méndez, Josefa Élida Poca Pastor, Ma Antonia Delgado Alvarez, Ignacio Macaya Ruíz, Alfons Hipocamp Trastorns de la memòria Infants prematurs - Malalties DISEASES::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Infant, Newborn, Diseases ANATOMY::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders ENFERMEDADES::enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades del recién nacido ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo::sistema límbico::hipocampo PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos Cervell; Investigació pediàtrica Cerebro; Investigación pediátrica Brain; Paediatric research Preterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term effects that GM-IVH have on hippocampal subfields, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced significantly lower total hippocampal volumes bilaterally and hippocampal subfield volumes compared to both low-risk preterm and full-term groups. Finally, significant positive correlations between memory and hippocampal subfield volumes were only found in preterm participants together; memory and the right CA-field correlation remained significant after Bonferroni correction was applied (p = .002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifically related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-field volume and memory during childhood. This study was funded by the Spanish Ministry of Science, Innovation and Universities [P.I.: L. Zubiaurre-Elorza (PSI2017-83657-P)]. L. Fernández de Gamarra-Oca, S. Soria-Pastor, R. L. Zubiaurre-Elorza, and E. Solana hold fellowships from the Basque Government (PRE_2019_1_0105), the Spanish Ministry of Education and Science (AP2005-0047) and (AP2008-0935) and the Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona respectively. We would like to extend special thanks to the families and the children who participated in this study. 2021-07-21T10:46:28Z 2021-07-21T10:46:28Z 2021-01-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Scientific Reports;11(1) https://www.nature.com/articles/s41598-021-81802-7 info:eu-repo/grantAgreement/ES/PE2013-2016/PSI2017-83657-P info:eu-repo/grantAgreement/ES/1PN/2004-2007/AP2005-0047 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Nature Research Scientia