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oai:recercat.cat:11351/61692025-10-24T10:15:59Zcom_2072_378070com_2072_378040col_2072_378092

Direct-acting antiviral therapy improves kidney survival in hepatitis C virus-associated cryoglobulinaemia: the RENALCRYOGLOBULINEMIC study Pérez de José, Ana Carbayo, Javier Pocurull, Anna Bada-Bosch, Teresa Cases Corona, Clara Maria Ramos Terrades, Natalia Shabaka, Amir Institut Català de la Salut [Pérez de José A, Carbayo J] Department of Nephrology, University Hospital Gregorio Marañón, Madrid, Spain. [Pocurull A] Department of Gastroenterology and Hepatology, Hospital Clínic de Barcelona, Barcelona, Spain. [Bada-Bosch T] Department of Nephrology, Hospital Universitario Doce de Octubre, Madrid, Spain. [Cases Corona CM] Department of Nephrology, Hospital Universitario Fundacion Alcorcon, Madrid, Spain. [Shabaka A] Department of Nephrology, Hospital Clínico Universitario San Carlos, Madrid, Spain. [Ramos Terrada N] Servei de Nefrologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Virus de l'hepatitis C Medicaments antivírics - Ús terapèutic - Eficàcia DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C::Hepatitis C, Chronic CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents Other subheadings::Other subheadings::/therapeutic use ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C::hepatitis C crónica COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos Otros calificadores::Otros calificadores::/uso terapéutico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento Crioglobulinèmia; Agents antivirals d’acció directa; Virus de l'hepatitis C Crioglobulinemia; Agentes antivirales de acción directa; Virus de la hepatitis C Cryoglobulinaemia; Direct-acting antiviral agents; Hepatitis C virus Background Direct-acting antiviral agents (DAAs) have shown high rates of sustained virological response in chronic hepatitis C virus (HCV) infection. However, the influence of DAAs on the course of kidney involvement in HCV-associated mixed cryoglobulinaemia (HCV-MC) has been little studied. The aim of this study was to analyse the effects of antiviral treatment on kidney prognosis and evolution in patients diagnosed with HCV-MC. Methods The RENALCRYOGLOBULINEMIC study is an observational multicentre cohort study of 139 patients with HCV-MC from 14 Spanish centres. Clinical and laboratory parameters were measured before and after antiviral treatment. Primary endpoints were kidney survival and mortality after HCV-MC diagnosis. Secondary endpoints were clinical, immunological and virological responses after antiviral treatment. Results Patients were divided into three groups based on the treatment received: treatment with DAAs (n = 100) treatment with interferon (IFN) and ribavirin (RBV) (n = 24) and no treatment (n = 15). Patients were followed up for a median duration of 138 months (interquartile range 70–251. DAA treatment reduced overall mortality {hazard ratio [HR] 0.12 [95% confidence interval (CI) 0.04–0.40]; P < 0.001} and improved kidney survival [HR 0.10 ( 95% CI 0.04–0.33); P < 0.001]. Conclusions Results from the RENALCRYOGLOBULINEMIC study indicated that DAA treatment in patients with HCV-MC improves kidney survival and reduces mortality. 2021-07-15T12:09:26Z 2021-07-15T12:09:26Z 2020-01-25 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pérez de José A, Carbayo J, Pocurull A, Bada-Bosch T, Cases Corona CM, Shabaka A, et al. Direct-acting antiviral therapy improves kidney survival in hepatitis C virus-associated cryoglobulinaemia: the RENALCRYOGLOBULINEMIC study. Clin Kidney J. 2020 Jan 25;14(2):586-592. 2048-8513 https://hdl.handle.net/11351/6169 10.1093/ckj/sfz178 33623683 000642298900017 http://hdl.handle.net/11351/6169 eng Clinical Kidney Journal;14(2) https://academic.oup.com/ckj/article/14/2/586/5716107 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf Oxford University Press Scientia