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oai:recercat.cat:11351/61272025-10-24T10:28:16Zcom_2072_378070com_2072_378040col_2072_378092

Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain Fernández-Cooke, Elisa Grasa, Carlos D. Domínguez-Rodríguez, Sara Barrios Tascón, Ana Giralt García, Gemma Anton, Jordi Sánchez-Manubens, Judith Institut Català de la Salut [Fernández-Cooke E] Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain. Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. [Grasa CD] Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario La Paz, Madrid, Spain. [Domínguez-Rodríguez S] Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. [Barrios Tascón A] Department of Pediatrics, Hospital Universitario Infanta Sofia, Madrid, Spain. [Sánchez-Manubens J, Anton J] Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Giralt G] Servei de Cardiologia Pediàtrica, Servei de Pediatria, Vall d'Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus COVID-19 (Malaltia) - Complicacions Limfadenitis Infants DISEASES::Cardiovascular Diseases::Vascular Diseases::Vasculitis::Mucocutaneous Lymph Node Syndrome DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation::Systemic Inflammatory Response Syndrome DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections Other subheadings::Other subheadings::Other subheadings::/complications ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::vasculitis::síndrome mucocutáneo linfonodular ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación::síndrome de respuesta inflamatoria sistémica ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Malaltia de Kawasaki (KD); Nens Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Enfermedad de Kawasaki (KD); Niños Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Kawasaki disease (KD); Children Introduction: COVID-19 has a less severe course in children. In April 2020, some children presented with signs of multisystem inflammation with clinical signs overlapping with Kawasaki disease (KD), most of them requiring admission to the pediatric intensive care unit (PICU). This study aimed to describe the prevalence and clinical characteristics of KD SARS-CoV-2 confirmed and negative patients during the pandemic in Spain. Material and Methods: Medical data of KD patients from January 1, 2018 until May 30, 2020 was collected from the KAWA-RACE study group. We compared the KD cases diagnosed during the COVID-19 period (March 1–May 30, 2020) that were either SARS-CoV-2 confirmed (CoV+) or negative (CoV–) to those from the same period during 2018 and 2019 (PreCoV). Results: One hundred and twenty-four cases were collected. There was a significant increase in cases and PICU admissions in 2020 (P-trend = 0.001 and 0.0004, respectively). CoV+ patients were significantly older (7.5 vs. 2.5 yr) and mainly non-Caucasian (64 vs. 29%), had incomplete KD presentation (73 vs. 32%), lower leucocyte (9.5 vs. 15.5 × 109) and platelet count (174 vs. 423 × 109/L), higher inflammatory markers (C-Reactive Protein 18.5vs. 10.9 mg/dl) and terminal segment of the natriuretic atrial peptide (4,766 vs. 505 pg/ml), less aneurysm development (3.8 vs. 11.1%), and more myocardial dysfunction (30.8 vs. 1.6%) than PreCoV patients. Respiratory symptoms were not increased during the COVID-19 period. Conclusion: The KD CoV+ patients mostly meet pediatric inflammatory multisystem syndrome temporally associated with COVID-19/multisystem inflammatory syndrome in children criteria. Whether this is a novel entity or the same disease on different ends of the spectrum is yet to be clarified. CG is funded by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III and Fondos FEDER (Contrato Río Hortega CM19/00015). 2021-07-06T12:36:45Z 2021-07-06T12:36:45Z 2021-01-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Fernández-Cooke E, Grasa CD, Domínguez-Rodríguez S, Barrios Tascón A, Sánchez-Manubens J, Anton J, et al. Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain. Front Pediatr. 2021 Jan 18;8:617039. 2296-2360 https://hdl.handle.net/11351/6127 10.3389/fped.2020.617039 33537269 000613446700001 http://hdl.handle.net/11351/6127 eng Frontiers in Pediatrics;8 https://www.frontiersin.org/articles/10.3389/fped.2020.617039/full info:eu-repo/grantAgreement/ES/PE2017-2020/CM19%2F00015 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Frontiers Media Scientia