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Metabolic fingerprint of acromegaly and its potential usefulness in clinical practice Biagetti Biagetti, Betina Herance Camacho, José Raul Ferrer Costa, Roser Aulinas, Anna Palomino-Schätzlein, Martina Mesa Manteca, Jordi Simó Canonge, Rafael [Biagetti B, Mesa J, Simó R] Grup de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Universidat Autònoma de Barcelona, Barcelona, Spain. [Herance J.R.] Grup de Recerca en Imatge Mèdica Molecular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Nanomedicina Oncologia molecular (CIBBIM-Nanomedicina), Barcelona, Spain. Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Ferrer R] Servei de Bioquímica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Aulinas A] Endocrinology Department, Hospital Universitari de Vic, Barcelona, Spain. [Palomino Schätzlein M] NMR Facility, Centro de Investigación Príncipe Felipe, Valencia, Spain Vall d'Hebron Barcelona Hospital Campus Acromegàlia Marcadors bioquímics - Anàlisi Aminoàcids DISEASES::Endocrine System Diseases::Pituitary Diseases::Hyperpituitarism::Acromegaly CHEMICALS AND DRUGS::Biological Factors::Biomarkers CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Branched-Chain Other subheadings::Other subheadings::/analysis ENFERMEDADES::enfermedades del sistema endocrino::enfermedades de la hipófisis::hiperpituitarismo::acromegalia COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::aminoácidos::aminoácidos de cadena ramificada Otros calificadores::Otros calificadores::/análisis Acromegaly; Metabolomics; Amino acids Acromegalia; Metabolómica; Aminoácidos Acromegàlia; Metabolòmica; Aminoàcids Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated comorbidities. The present study was aimed at identifying metabolites that could be used as biomarkers for a better disease phenotyping. For this purpose, metabolic fingerprint using an untargeted metabolomic approach was examined in serum from 30 patients with acromegaly and 30 age-matched controls. Patients with acromegaly presented fewer branched-chain amino acids (BCAAs) compared to the control group (valine: 4.75 ± 0.87 vs. 5.20 ± 1.06 arbitrary units (AUs), p < 0.05; isoleucine: 2.54 ± 0.41 vs. 2.80 ± 0.51 AUs; p < 0.05). BCAAs were also lower in patients with active disease compared to patients with normal levels of IGF-1 with or without medical treatment. GH, but not IGF-1, serum levels were inversely correlated with both valine and isoleucine. These findings indicate that low levels of BCAAs represent the main metabolic fingerprint of acromegaly and that GH, rather than IGF-1, might be the primary mediator. In addition, our results suggest that the assessment of BCAAs could help to identify active disease and to monitor the response to therapeutic strategies. This research was funded by Pfizer Global Investigator Initiated Research. J.P.C. and R.M.L. are funded by Junta de Andalucía (CTS-1406, BIO-0139), Ministerio de Ciencia, Innovación y Universidades (BFU2016-80360-R), and Instituto de Salud Carlos III, co-funded by European Union (ERDF/ESF, “Investing in your future”: PI16/00264, CP15/00156 and CIBERobn). CIBER is an initiative of Instituto de Salud Carlos III. 2020-07-28T09:06:38Z 2020-07-28T09:06:38Z 2019-09-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Biagetti B, Herance J.R., Ferrer R, Aulinas A, Palomino-Schätzlein M, Mesa J, et al. Metabolic fingerprint of acromegaly and its potential usefulness in clinical practice. J Clin Med. 2019 Sep 26;8(10):1549. 2077-0383 https://hdl.handle.net/11351/5111 10.3390/jcm8101549 31561638 000498398500047 http://hdl.handle.net/11351/5111 eng Journal of Clinical Medicine;8(10) https://www.mdpi.com/2077-0383/8/10/1549 info:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F00264 info:eu-repo/grantAgreement/ES/PE2013-2016/CP15%2F00156 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI Scientia