2026-04-17T06:34:27Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/50662025-10-24T10:35:23Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Torres-Salido, Maria Teresa author Sanchis Marin, Mireia author Solé Marce, Cristina author Moline Marimon, Teresa author Vidal, Marta author Vidal Guitart, Xavier author Ordi Ros, José author Cortés Hernandez, Josefina author 2020-07-06T13:03:45Z 2020-07-06T13:03:45Z 2019-09-17 Neuropilin-1; Lupus nephritis; Urinary biomarker Neuropilina-1; Nefritis lúpica; Biomarcador urinario Neuropilina-1; Nefritis per lupus; Biomarcador urinari At present, Lupus Nephritis (LN) is still awaiting a biomarker to better monitor disease activity, guide clinical treatment, and predict a patient’s long-term outcome. In the last decade, novel biomarkers have been identified to monitor the disease, but none have been incorporated into clinical practice. The transmembrane receptor neuropilin-1 (NRP-1) is highly expressed by mesangial cells and its genetic deletion results in proteinuric disease and glomerulosclerosis. NRP-1 is increased in kidney biopsies of LN. In this work we were interested in determining whether urinary NRP-1 levels could be a biomarker of clinical response in LN. Our results show that patients with active LN have increased levels of urinary NRP-1. When patients were divided according to clinical response, responders displayed higher urinary and tissue NRP-1 levels at the time of renal biopsy. Areas under the receiver operating characteristic curve, comparing baseline creatinine, proteinuria, urinary NRP-1, and VEGFA protein levels, showed NRP-1 to be an independent predictor for clinical response. In addition, in vitro studies suggest that NRP-1could promote renal recovery through endothelial proliferation and migration, mesangial migration and local T cell cytotoxicity. Based on these results, NRP-1 may be used as an early prognostic biomarker in LN. This work was supported by grants from the Spain Government (Instituto de Salud Carlos III). This research also received donations from Catalan Lupus Foundation and A.Bosch Foundation. http://hdl.handle.net/11351/5066 Lupus eritematós sistèmic Marcadors bioquímics Prognosi DISEASES::Immune System Diseases::Autoimmune Diseases::Lupus Erythematosus, Systemic::Lupus Nephritis CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Neuropilins::Neuropilin-1 ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis ENFERMEDADES::enfermedades del sistema inmune::enfermedades autoinmunes::lupus eritematoso sistémico::nefritis lúpica COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas::receptores de superficie celular::neuropilinas::neuropilina-1 TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::Diagnóstico::Pronóstico Urinary neuropilin-1: a predictive biomarker for renal outcome in lupus nephritis