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oai:recercat.cat:11351/47072026-04-04T03:15:17Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Sánchez Montalvá, Adrián author Barios Profitós, Marta author Villar Gomez, Ana author Tórtola Fernández, Mª Teresa author Molina Morant, Daniel author Lorenzo Bosquet, Carles author Espinosa Pereiro, Juan author Molina Romero, Israel author Salvador Velez, Fernando M author 2020-03-06T11:22:11Z 2020-03-06T11:22:11Z 2019-08-27 Tuberculosis; Positron emission tomography (PET); FDG Tuberculosis; Tomografía por emisión de positrones (PET); FDG Tuberculosi; Tomografia per emissió de positrons (PET); FDG BACKGROUND: The aim of our study is to describe the FDG-PET/CT findings in patients with tuberculosis and to correlate them with the patient's prognosis. METHODS: We retrospectively collected data from patients with tuberculosis, who had an FDG-PET/CT performed prior to treatment initiation from 2010 to 2015. RESULTS: Forty-seven out of 504 patients with active tuberculosis diagnosis (9.33%) underwent an FDG-PET/CT. The reasons for performing the FDG-PET/CT were: characterization of a pulmonary nodule (24; 51.1%), study of fever of unknown origin (12; 25.5%), study of lymph node enlargement (5; 10.6%) and others (6; 12.8%). Median age was 64 (IQR 50-74) years and 31 (66%) patients were male. Twenty-six (55.3%) patients had an immunosuppressant condition. According to the FDG-PET/CT, 48.6% of the patients had more than 1 organ affected and 46.8% had lymph node involvement. Median SUVmax of the main lesion was 5 (IQR 0.28-11.85). We found an association between the FDG accumulation and the size of the main lesion with a correlation coefficient of 0.54 (p<0.002). Patients with an unsuccessful outcome had a higher ratio SUVmax main lesion / SUVmean liver (1.92 vs 7.67, p<0.02). CONCLUSIONS: In our cohort, almost half of the patients had more than 1 organ affected and 46.8% of them had lymph node involvement. FDG uptake was associated with the size of the main lesion and seems to be related to the treatment outcome. The extent of its potential to be used as an early predictor of treatment success still needs to be defined. Tuberculosi Tomografia per emissió de positrons Radiofàrmacs ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, Emission-Computed::Positron-Emission Tomography::Positron Emission Tomography Computed Tomography CHEMICALS AND DRUGS::Carbohydrates::Deoxy Sugars::Deoxyglucose::Fluorodeoxyglucose F18 DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::Tuberculosis ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones por Actinomycetales::micobacteriosis::tuberculosis TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::interpretación de imágenes asistida por ordenador::tomografía computarizada radioisotópica::tomografía por emisión de positrones COMPUESTOS QUÍMICOS Y DROGAS::hidratos de carbono::desoxiazúcares::desoxiglucosa::fluorodesoxiglucosa F18 Usefulness of FDG PET/CT in the management of tuberculosis