2026-04-18T02:20:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/46332025-10-24T10:22:30Zcom_2072_378070com_2072_378040col_2072_378092

Nerve-sparing versus non-nerve-sparing radical hysterectomy: surgical and long-term oncological outcomes Gil Moreno, Antonio Carbonell Socias, Melchor Salicrú Riera, Sabina Bradbury Lobato, Melissa García Jiménez, Angel Vergés Capdevila, Ramona Puig Puig, Oriol Sánchez Iglesias, José Luis Cabrera Diaz, Silvia De la Torre Fdez de Vega, Fco Javier Perez Benavente, Maria Asuncion Rodriguez Gómez-Hidalgo, Natalia Díaz-Feijoo, Berta [Gil-Moreno A, Carbonell-Socias M, Salicrú S, Bradbury M, Puig OP, Sánchez-Iglesias JL, Cabrera-Díaz S, de-la-Torre J, Gómez-Hidalgo NR, Pérez-Benavente A, Díaz-Feijoo B] Unitat de Ginecologia Oncològica, Servei d’Obstetrícia i Ginecologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [García Á] Servei de Patologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Vergés R] Servei de Radioteràpia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Vall d'Hebron Barcelona Hospital Campus Histerectomia Coll uterí - Càncer Anàlisi de supervivència (Biometria) ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Urogenital Surgical Procedures::Gynecologic Surgical Procedures::Hysterectomy DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Uterine Cervical Neoplasms ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos urogenitales::procedimientos quirúrgicos ginecológicos::histerectomía ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas::neoplasias del cuello uterino TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis de supervivencia Cervical cancer; Surgical treatment; Morbidity Càncer cervical; Tractament quirúrgic; Morbilidad Càncer cervical; Tractament quirúrgic; Morbiditat OBJECTIVES: There are controversies regarding the long-term oncological safety of preservation of pelvic innervation during radical hysterectomy (RH). This study aimed to analyze the feasibility and safety of nerve-sparing radical hysterectomy (NSRH) for cervical cancer compared with non-NSRH following 17 years of experience in a tertiary cancer referral center. MATERIALS AND METHODS: Between May 1999 and June 2016, all patients who underwent RH for cervical cancer were followed-up prospectively. Comparison analyses regarding surgical outcomes, complications, overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) were performed between patients treated with NSRH and non-NSRH. RESULTS: A total of 188 patients were included (113 non-NSRH and 75 NSRH). The median follow-up was 112 months. Estimated blood loss and hospital stay were all significantly lower in the NSRH group. Overall intraoperative complication rate (p = 0.02) and need for transfusion (p = 0.016) were lower in the NSRH group. There were no differences in the median operation time, OS, DFS, CSS, or recurrence rates between the NSRH and non-NSRH group. CONCLUSIONS: Our study provides a wide perspective on the developments of nerve-sparing procedures for the management of women with early-stage cervical cancer. Our results suggest that NSRH is a feasible and safe procedure, with reduced morbidity outcomes. 2020-02-14T12:41:57Z 2020-02-14T12:41:57Z 2019-07-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gil-Moreno A, Carbonell-Socias M, Salicrú S, Bradbury M, García A, Vergés R, et al. Nerve-sparing versus non-nerve-sparing radical hysterectomy: surgical and long-term oncological outcomes. Oncotarget. 2019 Jul 16;10(44):4598–608. 1949-2553 https://hdl.handle.net/11351/4633 10.18632/oncotarget.27078 31360307 http://hdl.handle.net/11351/4633 eng Oncotarget;10(44) http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=27078&path[]=86082 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf Impact Journals Scientia