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oai:recercat.cat:11351/37852025-10-24T10:30:24Zcom_2072_378070com_2072_378040col_2072_378092

Long-term probability of intraocular pressure elevation with the intravitreal dexamethasone implant in the real-world Sala-Puigdollers, Anna Velázquez Villoria, Daniel Figueras-Roca, Marc Copete, Sergio Distefano, Laura Natalia García Arumí, José Boixadera Espax, Ana Zarranz-Ventura, Javier Institut Català de la Salut [Zarranz-Ventura J, Sala-Puigdollers A, Figueras-Roca M] Institut Clínic d'Oftalmologia, Hospital Clínic, Barcelona, Spain. [Velazquez-Villoria D, Copete S, Distefano L, Boixadera A, García-Arumí J] Servei d'Oftalmologia, Hospital Universitari Vall d’Hebron, Barcelona, Spain. Vall d'Hebron Barcelona Hospital Campus Pressió intraocular Injeccions Dexametasona PHENOMENA AND PROCESSES::Ocular Physiological Phenomena::Intraocular Pressure CHEMICALS AND DRUGS::Polycyclic Compounds::Fused-Ring Compounds::Steroids::Polycyclic Compounds::Fused-Ring Compounds::Steroids::Steroids, Fluorinated::Dexamethasone ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT::Therapeutics::Drug Therapy::Drug Administration Routes::Injections::Injections, Intraocular::Intravitreal Injections FENÓMENOS Y PROCESOS::fenómenos fisiológicos oculares::presión intraocular COMPUESTOS QUÍMICOS Y DROGAS::compuestos policíclicos::compuestos con anillos de fusión::esteroides::compuestos policíclicos::compuestos con anillos de fusión::esteroides::esteroides fluorados::dexametasona TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::vías de administración de medicamentos::inyecciones::inyecciones intraoculares::inyecciones intravítreas Intraocular pressure; Intravitreal dexamethasone Pressió intraocular; Dexametasona intravitrea Presión intraocular; Dexametasona intravítrea PURPOSE: To evaluate the long-term cumulative probability of intraocular pressure (IOP) elevation with the intravitreal dexamethasone implant (IDI) when used to treat different indications: diabetic macular edema, uveitis, retinal vein occlusion. METHODS: 705 IDI injections (429 eyes) were assessed and Kaplan-Meier graphs were generated to assess: the probability of different levels of IOP elevation (IOP≥21, ≥25 or ≥35 mmHg), IOP change ≥10 mmHg, initiation of IOP-lowering treatment, glaucoma surgery, IOP change with repeat injections and IOP elevation in eyes with glaucoma and ocular hypertension (OHT). RESULTS: The cumulative probability of IOP ≥21, ≥25 and ≥35 mmHg was 50%-60%, 25%-30% and 6%-7% at 12-24 months, respectively. The probability of initiating IOP-lowering medication was 31%-54% at 12-24 months. Glaucoma and OHT eyes had a higher probability of mild IOP elevation (≥21 mmHg, 65.1%, 75% and 57.8%, p = 0.01), yet a similar moderate (≥25 mmHg, 22.3%, 28% and 30.2%, p = 0.91) and severe elevation of IOP (≥35 mmHg, 3.7%, 7.1% and 4%, p = 0.71) as normal eyes. Glaucoma surgery was required in only 0.9% cases (4/429). At baseline, 8.8% of the treated eyes had glaucoma, 6.7% OHT and 16.9% were already on IOP-lowering medication. CONCLUSIONS: In the long-term (24 months), IOP elevation is common, generally mild (30% IOP, ≥25 mmHg) and well-tolerated, resolving with topical treatment (54%) and rarely requiring surgery (0.9%). 2019-02-12T07:04:59Z 2019-02-12T07:04:59Z 2019-01-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Zarranz-Ventura J, Sala-Puigdollers A, Velazquez-Villoria D, Figueras-Roca M, Copete S, Distefano L, et al. Long-term probability of intraocular pressure elevation with the intravitreal dexamethasone implant in the real-world. PLoS One. 2019;14(1):e0209997. 1932-6203 https://hdl.handle.net/11351/3785 10.1371/journal.pone.0209997 30608950 WOS:000454952800035 http://hdl.handle.net/11351/3785 eng PLoS One;14(1) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209997 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf Public Library of Science Scientia