2026-04-17T13:56:08Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/35202025-10-24T07:47:31Zcom_2072_378068com_2072_378040col_2072_378090

2025-10-24T07:47:31Z urn:hdl:11351/3520 Statins and new-onset atrial fibrillation in a cohort of patients with hypertension: analysis of electronic health records, 2006-2015 García-Gil, Maria Parramon, Dídac Blanch-Andreu, Jordi Elosua-Bayes, Marc Ramos, Rafel Martí Lluch, Ruth Comas-Cufí, Marc Alves-Cabratosa, Lia Ponjoan, Anna Fibril·lació auricular Hipertensió DISEASES::Cardiovascular Diseases::Heart Diseases::Arrhythmias, Cardiac::Atrial Fibrillation ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Records as Topic::Medical Records::Health Records, Personal::Electronic Health Records DISEASES::Cardiovascular Diseases::Vascular Diseases::Hypertension ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::arritmias cardíacas::fibrilación atrial TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::registros::registros médicos::sistemas informatizados de historias clínicas::historias clínicas electrónicas ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::hipertensión Atrial Fibrillation; Electronic Health Records; Hypertension Fibrilación atrial; Registros Electrónicos de Salud; Hipertensión Fibril·lació atrial ; Registres Electrònics de Salut; Hipertensió Hypertension is the most prevalent risk factor for new-onset atrial fibrillation (AF). But few studies have addressed the effect of statins on the incidence of this arrhythmia in patients with hypertension. This study aimed to evaluate the effect of statins on new-onset of this arrhythmia in a hypertensive population, accounting for AF risk. Data from the Information System for the Development of Research in Primary Care was used to recruit a retrospective cohort of ≥55-year-old hypertensive individuals with no ischemic vascular disease, in 2006-2007, followed up through 2015. The effect of initiating statin treatment on new-onset atrial fibrillation was assessed with Cox proportional hazards models adjusted by the propensity score of receiving statin treatment, in the overall study population and stratified by AF risk. Of 100 276 included participants, 9814 initiated statin treatment. The AF incidence per 1000 person-years (95% confidence interval) was 12.5 (12.3-12.8). Statin use associated with a significant (9%) reduction in AF incidence. Differences in absolute AF incidence were higher in the highest AF risk subgroup, and the estimated number needed to treat to avoid one case was 720. The relative effect was poor, similar across groups, and non-significant, as was the association of statins with adverse effects. We found a limited protective effect of statins over new-onset AF in this hypertensive population with no ischemic vascular disease. If there is no further indication, hypertensive patients would not benefit from statin use solely for AF primary prevention. 2025-10-24T07:47:31Z 2025-10-24T07:47:31Z 2018-06-18T09:38:29Z 2018-06-18T09:38:29Z 2017-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/3520 PLoS ONE;12(10) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186972 Atribución-NoComercial-SinDerivadas 3.0 España http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Public Library of Science Scientia