2026-04-14T03:16:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/138752025-10-24T10:23:21Zcom_2072_378070com_2072_378040col_2072_378092

Recurrent Pneumothorax in a Pediatric Patient with Crohn’s Disease Receiving Ustekinumab Treatment: Case Report Freixas Bermejo, Marta Riera Soler, Luis García Martínez, Laura Segarra, Oscar Crohn, Malaltia de - Tractament Anticossos monoclonals - Ús terapèutic - Efectes secundaris Pneumotòrax DISEASES::Respiratory Tract Diseases::Pleural Diseases::Pneumothorax DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Disease Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::enfermedades respiratorias::enfermedades pleurales::neumotórax ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal::enfermedad de Crohn Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos Crohn disease; Inflammatory bowel disease; Pneumothorax Malaltia de Crohn; Malaltia inflamatòria intestinal; Pneumotòrax Enfermedad de Crohn; Enfermedad inflamatoria intestinal; Neumotórax Introduction: We present the case of a patient with Crohn's disease who experienced recurrent pneumothorax after starting treatment with ustekinumab. Case presentation: A patient with Crohn's disease started an induction regimen with intravenous ustekinumab, and 2 months later he presented a left-sided pneumothorax. It had an atypical evolution that required surgical management. The medication was withdrawn and the pneumothorax resolved completely. One year later, he had a new flare-up of Crohn's disease and ustekinumab therapy was restarted, presenting a new episode of pneumothorax. Conclusion: To our knowledge, this is the first report of recurrent pneumothorax following two separate attempts to initiate ustekinumab. 2025-10-24T10:23:21Z 2025-10-24T10:23:21Z 2025-10-24T10:23:21Z 2025-10-16T07:23:15Z 2025-10-16T07:23:15Z 2025 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/13875 Case Reports in Gastroenterology;19(1) https://doi.org/10.1159/000543991 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Karger Scientia