2026-04-13T04:13:05Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/138192025-10-24T10:28:35Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Demirci, Nuri
author
YILGOR, CAGLAR
author
zulemyan, tais
author
Balaban, Barış
author
Yucekul, Altug
author
Haddad, Sleiman
author
Pellise, Ferran
2025-10-24T10:28:35Z
2025-10-24T10:28:35Z
2025-10-09T10:43:28Z2025-10-09T10:43:28Z2025-07
http://hdl.handle.net/11351/13819
Mechanical complications; Spinal deformity; Postoperative alignmentComplicaciones mecánicas; Deformidad espinal; Alineación postoperatoriaComplicacions mecàniques; Deformitat espinal; Alineació postoperatòriaObjective: Mechanical complications are common after adult spinal deformity (ASD) surgery and can significantly impair outcomes. This study aimed to predict such complications in proportioned and moderately disproportioned patients using a machine learning approach, to inform preoperative planning and enable early preventive care.
Methods: Prospectively collected clinical data, including preoperative, intraoperative, and postoperative variables, radiographic param- eters, technical details, and patient-reported outcomes, were obtained from a multi-center ASD surgery database. Parameter tuning of a random forest (RF) classifier was performed using 9-times 3-fold cross-validation over 3 rounds of grid search, with the F-score used as the primary optimization metric. The final RF model was used to derive a clinically interpretable rule set using the inTrees framework. Permutation-based feature importance was assessed for F-score, accuracy, and sensitivity.
Results: The model was trained on 295 patients (237 female, 58 male; mean age, 50 ± 19 years) with a minimum 2-year follow-up (mean 53 months, range 24-101). Mechanical complications were observed in 100 patients (34%). A test cohort of 98 patients (33% complication rate) was used for external validation. The RF model achieved 72% accuracy, 91% sensitivity, 64% specificity, and 93% negative predictive value. The derived rule set, comprising 8 rules using 1 to 3 features each, yielded 74% accuracy, 81% sensitivity, 71% specificity, and 83% negative predictive value. The location of the lower instrumented vertebra (LIV) was the most influential predictor.
Conclusion: By excluding patients with severe deformities, as defined by the GAP score, this study focused on the more clinically ambiguous group of proportioned and moderately disproportioned patients. To the authors’ knowledge, this is the first study to develop predictive tools specifically for this subgroup to assess the risk of mechanical complications following ASD surgery. These tools may assist in early risk stratification and guide preoperative decision-making to reduce postoperative complications and improve patient outcomes.
Level of Evidence: Level III, Prognostic Study.
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess
Escoliosi - Cirurgia - Complicacions
Columna vertebral - Malformacions - Cirurgia - Complicacions
Aprenentatge automàtic
PHENOMENA AND PROCESSES::Mathematical Concepts::Algorithms::Artificial Intelligence::Machine Learning
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Postoperative Complications
DISEASES::Musculoskeletal Diseases::Bone Diseases::Spinal Diseases::Spinal Curvatures
Other subheadings::Other subheadings::Other subheadings::/surgery
DISEASES::Musculoskeletal Diseases::Bone Diseases::Spinal Diseases::Spinal Curvatures::Scoliosis
FENÓMENOS Y PROCESOS::conceptos matemáticos::algoritmos::inteligencia artificial::aprendizaje automático
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::complicaciones posoperatorias
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades óseas::enfermedades de la columna vertebral::desviaciones de la columna vertebral
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades óseas::enfermedades de la columna vertebral::desviaciones de la columna vertebral::escoliosis
Predicting mechanical complications in adult spinal deformity patients with postoperative proportioned and moderately disproportioned alignment
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion