2026-04-13T22:08:33Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/137892025-10-24T08:50:36Zcom_2072_378070com_2072_378040com_2072_378071col_2072_378092col_2072_378097
RECERCAT
author
KRUPINSKI, JERZY
author
Lanzillo, Roberta
author
Buongiorno, Mariateresa
author
TUR, CARMEN
author
Giraldo, Darly M.
author
Cullell, Natalia
2025-10-24T08:50:36Z
2025-10-24T08:50:36Z
2025-10-06T10:29:55Z2025-10-06T10:29:55Z2025-07
http://hdl.handle.net/11351/13789
Multiple sclerosis; Neurodegeneration; SleepEsclerosis múltiple; Neurodegeneración; DormirEsclerosi múltiple; Neurodegeneració; DormirEpidemiological studies identified insufficient and poor-quality sleep as independent risk factors for multiple sclerosis (MS). The glymphatic system, active during slow-wave sleep, clears brain waste through perivascular astrocytic aquaporin-4 (AQP4) channels. The presence of antigens induces a transient, physiological lowering of glymphatic flux as a first step of an inflammatory response. A possible hypothesis linking infection with the Epstein-Barr virus, a well identified causal step in MS, and the development of the disease is that mechanisms such as poor sleep or less functional AQP4 polymorphisms may sustain glymphatic flow reduction. Such chronic glymphatic reduction would trigger a vicious circle in which the persistence of antigens and an inflammatory response maintains glymphatic dysfunction. In addition, viral proteins that persist in demyelinated plaques can depolarize AQP4, further restricting waste elimination and sustaining local inflammation. This review examines the epidemiological evidence connecting sleep and MS risk, and the mechanistic findings showing how poor sleep and other glymphatic modulators heighten inflammatory signaling implicated in MS pathogenesis. Deepening knowledge of glymphatic functioning in MS could open new avenues for personalized prevention and therapy.GS-B receives support from grant CP23/00039, funded by the Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union/FSE+ and the MCIN/AEI/10.13039/501100011033, through project PID2020-119556RA-I00.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Esclerosi múltiple - Factors de risc
Inflamació
Son
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
PHENOMENA AND PROCESSES::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Sleep
ANATOMY::Nervous System::Central Nervous System::Brain::Glymphatic System
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo
FENÓMENOS Y PROCESOS::fenómenos fisiológicos nerviosos y musculoesqueléticos::fenómenos fisiológicos del sistema nervioso::sueño
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo::sistema glinfático
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación
Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion