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oai:recercat.cat:11351/137482025-10-24T10:17:39Zcom_2072_378070com_2072_378040col_2072_378092

Efficacy and Safety of Open-Conjunctiva Ab Externo 63 µm vs. 45 µm XEN® Gel Stent in Glaucoma Surgery: One-Year Follow-Up Bertolani, Yann Rigo-Quera, Jaume Sánchez Vela, Laura Pujol, Olívia Amilburu, Manuel Dou, Antonio Castany, Marta Institut Català de la Salut [Bertolani Y, Rigo-Quera J, Sánchez-Vela L, Pujol-Carreras O, Amilburu M, Dou A, Castany M] Servei d’Oftalmologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Avaluació de resultats (Assistència sanitària) Glaucoma - Cirurgia endoscòpica Pròtesis de Stent ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Minimally Invasive Surgical Procedures DISEASES::Eye Diseases::Ocular Hypertension::Glaucoma Other subheadings::Other subheadings::Other subheadings::/surgery ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Equipment and Supplies::Prostheses and Implants::Stents TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos mínimamente invasivos ENFERMEDADES::oftalmopatías::hipertensión ocular::glaucoma Otros calificadores::Otros calificadores::Otros calificadores::/cirugía TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::equipos y suministros::prótesis e implantes::stents Intraocular surgery; Minimally invasive glaucoma surgery; Open-conjunctiva approach Cirugía intraocular; Cirugía de glaucoma mínimamente invasiva; Abordaje conjuntival abierto Cirurgia intraocular; Cirurgia de glaucoma mínimament invasiva; Abordatge conjuntival obert Background: To compare the efficacy and safety of the XEN® 63 µm and 45 µm devices with the ab externo open conjunctiva with a 30G needle approach. Methods: A retrospective, non-randomized and single-center study was conducted. Consecutive eyes undergoing a XEN® 63 µm implant were compared with a matched cohort of cases with a XEN® 45 µm implant. Standalone and combined procedures with phacoemulsification were included. Results: A total of 28 XEN® 45 µm and 28 XEN® 63 µm were included. Complete surgical success was achieved in 17 cases (60.7%) in the 45 µm group and in 20 cases (71.4%) in the 63 µm group, with no statistical differences. One year after the surgery, the mean IOP was 13.8 ± 3.3 mmHg for the 45 µm group and 12.4 ± 4.2 mmHg for the 63 µm group (p-value > 0.05). Likewise, the use of glaucoma medication was lowered in the 63 µm device (0.32 ± 0.87) compared to the 45 µm device (0.39 ± 0.86), with no statistical significance. Postoperative hypotony was more frequent in the 63 µm device (39.3%) than in the 45 µm group (28.6%), with no statistical differences. However, hypotony-associated complications (including choroidal detachment, hypotony keratopathy, and hypotony maculopathy) were significantly higher in the 63 µm group (p = 0.011). Conclusions: Although the XEN® 63 µm may offer a greater IOP-lowering effect with better complete surgical success, no significant differences were detected compared to the 45 µm device. Hypotony-related complications were higher in the XEN 63 µm, although most of them resolved with conservative management. 2025-09-29T12:28:16Z 2025-09-29T12:28:16Z 2025-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bertolani Y, Rigo-Quera J, Sánchez-Vela L, Pujol-Carreras O, Amilburu M, Dou A, et al. Efficacy and Safety of Open-Conjunctiva Ab Externo 63 µm vs. 45 µm XEN® Gel Stent in Glaucoma Surgery: One-Year Follow-Up. J Clin Med. 2025 May;14(10):3545. 2077-0383 http://hdl.handle.net/11351/13748 10.3390/jcm14103545 40429540 001497519100001 http://hdl.handle.net/11351/13748 eng Journal of Clinical Medicine;14(10) https://doi.org/10.3390/jcm14103545 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI Scientia