2026-04-05T11:41:57Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/136252025-10-24T10:31:57Zcom_2072_378070com_2072_378040col_2072_378092

Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma Adams, Madeleine Bertolini, Patrizia Chatziantoniou, Cyrano van Ewijk, Roelof Bisogno, Gianni BOUHAMAMA, Amine Coma, Ana Gallego, Soledad Infants Músculs - Càncer - Imatgeria per ressonància magnètica Imatges - Processament - Tècniques digitals NAMED GROUPS::Persons::Age Groups::Child DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Muscle Tissue::Myosarcoma::Rhabdomyosarcoma Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging::Diffusion Magnetic Resonance Imaging ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnosis, Computer-Assisted::Image Interpretation, Computer-Assisted DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido muscular::miosarcoma::rabdomiosarcoma Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética::imagen de resonancia magnética de difusión TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::diagnóstico asistido por ordenador::interpretación de imágenes asistida por ordenador Adolescent; Diffusion magnetic resonance imaging; Rhabdomyosarcoma Adolescent; Ressonància magnètica de difusió; Rabdomiosarcoma Adolescente; Resonancia magnética de difusión; Rabdomiosarcoma Background: The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is a potential biomarker for treatment response in pediatric rhabdomyosarcoma. Due to its rarity, investigations into this marker require multicenter approaches, which can result in variability in acquisition parameters. Objective: To evaluate the impact of different acquisition parameters on ADC estimates in a multicenter dataset of rhabdomyosarcoma patients. Materials and methods: We included 114 pediatric and adolescent rhabdomyosarcoma patients from 22 treatment centers (195 scans). Median age: 6.0 years (0.3-21.8). We evaluated the impact of voxel size, (number of) b-values, and echo time on tumor ADC values. The effect of the highest b-value was separately investigated on a subset of scans with five or more b-values. Results: We observed a large variability in key acquisition parameters in the overall cohort, and for individual imaging centers. No parameter showed a significant effect on ADC estimates of the whole cohort when corrected for multiple-comparisons. Decreasing the highest b-value within the same acquisition caused ADC to decrease on average by 2.8% per 100 s mm-2. Differing b-values between scans at diagnosis and treatment response yielded significant changes in the longitudinal ADC for each patient (P<0.05). Conclusion: While we observed wide variation of acquisition parameters within a multicenter cohort, this did not lead to significant cross-sectional differences of tumor ADC. However, we found that modifying the highest b-value between baseline and follow-up can impact longitudinal ADC estimates. As such, we recommend the highest b-value to remain constant. This retrospective study was reviewed and approved by the Internal Review Board (UMC Utrecht, reference ID: 18-412). 2025-10-24T10:31:57Z 2025-10-24T10:31:57Z 2025-09-09T08:14:45Z 2025-09-09T08:14:45Z 2025-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/13625 Pediatric Radiology;55(8) https://doi.org/10.1007/s00247-025-06263-w Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Springer Scientia