2026-04-17T07:51:46Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/135722025-10-24T10:41:02Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc iza, maider author Pallero Castillo, Mercedes author Salvadó Figueras, Maria author Ramos, Daniel author Llaurado, Arnau author Restrepo Vera, Juan Luis author Granados Rosales, Galo David author Alemañ Díez, Jose author Sotoca, Javier author Sampol, Júlia author MARTI, SERGI author Sánchez-Tejerina, Daniel author Juntas Morales, Raúl author 2025-08-25T08:07:41Z 2025-08-25T08:07:41Z 2025-06 Hepatitis E virus; Neuralgic amyotrophy; Neurologic manifestations Virus de la hepatitis E; Amiotrofia neurálgica; Manifestaciones neurológicas Virus de l'hepatitis E; Amiotròfia neuràlgica; Manifestacions neurològiques Aim: This study aimed to describe neurological manifestations secondary to hepatitis E virus (HEV) through the description of two clinical cases. Methods: Two different cases of neuralgic amyotrophy and meningoradiculitis are evaluated in the emergency department of a tertiary referral hospital in 2024. Results: Case 1: A 43-year-old male presented to the emergency department with proximal weakness and pain in the right upper extremity associated with acute onset of orthopnea. Laboratory tests revealed elevated AST/ALT levels (184/1164 IU/L) and positive HEV IgM and IgG, with detectable serum HEV viral load. Cerebrospinal fluid (CSF) was negative for HEV RNA. A significant decrease in forced vital capacity was observed on transition from the upright to the supine position. Electromyography showed severe bilateral phrenic nerve involvement. The diagnosis of neuralgic amyotrophy with diaphragmatic paralysis secondary to HEV was made. The patient was treated with intravenous immunoglobulins and noninvasive ventilation with partial improvement. Case 2: A 37-year-old male presented to the emergency department with paresthesias and weakness, initially affecting the distal upper and lower extremities and progressing proximally. Laboratory tests showed elevated AST/ALT levels (238/626 IU/L), positive HEV IgM and IgG, and a detectable HEV viral load in serum. HEV RNA was also detected in the CSF. Neurophysiological findings were normal. The patient was diagnosed with acute meningoradiculitis secondary to HEV. Treatment with intravenous immunoglobulins led to complete resolution of symptoms. Conclusions: In cases of acute neurological symptoms and liver dysfunction, HEV should be considered as a potential causative agent. http://hdl.handle.net/11351/13572 Virus de l'hepatitis E Neuràlgia cervicobraquial - Diagnòstic DISEASES::Nervous System Diseases::Neuromuscular Diseases::Peripheral Nervous System Diseases::Brachial Plexus Neuropathies::Brachial Plexus Neuritis Other subheadings::Other subheadings::/diagnosis DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis E DISEASES::Nervous System Diseases::Neurologic Manifestations ENFERMEDADES::enfermedades del sistema nervioso::enfermedades neuromusculares::enfermedades del sistema nervioso periférico::neuropatías del plexo braquial::neuritis del plexo braquial Otros calificadores::Otros calificadores::/diagnóstico ENFERMEDADES::virosis::hepatitis viral humana::hepatitis E ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas Neurological Manifestations of HEV Infection: A Rare Phenomenon or an Underrecognized Reality?