2026-04-17T06:02:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/135332025-10-24T10:44:25Zcom_2072_378070com_2072_378040col_2072_378092

2025-10-24T10:44:25Z urn:hdl:11351/13533 The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment Navarro Díaz, Maruja López-Martínez, Marina Ronyons - Malalties - Tractament Ronyons - Malalties - Diagnòstic Obesitat Marcadors bioquímics MicroARN DISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity CHEMICALS AND DRUGS::Biological Factors::Biomarkers CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases Other subheadings::Other subheadings::/diagnosis HEALTH CARE::Health Services Administration::Patient Care Management::Disease Management ENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARN ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales Otros calificadores::Otros calificadores::/diagnóstico ATENCIÓN DE SALUD::administración de los servicios de salud::gestión de la atención al paciente::tratamiento de las enfermedades Biomarker; MicroRNA; Obesity-related glomerulopathy Biomarcador; MicroARN; Glomerulopatia relacionada amb l'obesitat Biomarcador; MicroARN; Glomerulopatía relacionada con la obesidad Obesity increases the risk of cardiovascular disease, diabetes and chronic kidney disease. Obesity-related glomerulopathy (ORG) is a potentially reversible cause of kidney disease that often progresses silently until it reaches irreversible stages. However, we are still lacking a sensitive and specific biomarker to identify patients with obesity who are at risk of developing CKD. The role of microRNAs (miRNAs) has emerged as a promising area for diagnostic and therapeutic applications in kidney disease. Recent research has highlighted the specific roles of various miRNAs in renal function, showing that their dysregulation can contribute to the development of kidney diseases. This review will discuss the emerging role of miRNAs in the context of ORG, focusing on their potential as biomarkers and therapeutic targets for this increasingly prevalent disease. 2025-10-24T10:44:25Z 2025-10-24T10:44:25Z 2025-08-18T08:26:08Z 2025-08-18T08:26:08Z 2025-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/13533 Biomedicines;13(5) https://doi.org/10.3390/biomedicines13051030 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess MDPI Scientia