2026-04-17T14:36:01Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/133702025-07-09T04:36:24Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Murphy, Danielle A.
author
Pu, Jie
author
Kopetz, Scott
author
Ciardiello, Fortunato
author
Desai, Jayesh
author
Van Cutsem, Eric
author
Tabernero, Josep
2025-07-09T04:36:23Z
2025-07-09T04:36:23Z
2025-07-08T10:52:11Z2025-07-08T10:52:11Z2025
http://hdl.handle.net/11351/13370
Colorectal cancer; MutationCàncer colorectal; MutacióCáncer colorrectal; MutaciónWhat is this summary about?
This summary discusses the genetic and molecular changes in tumors of participants with BRAF V600E–mutant metastatic colorectal cancer who were treated with encorafenib plus cetuximab, with or without binimetinib, in the BEACON study.
What were the results?
Encorafenib plus cetuximab, with or without binimetinib, reduced the risk of participants dying compared with cetuximab plus chemotherapy, regardless of genetic or molecular colorectal cancer subtypes.
The study also found genetic and molecular changes in the participants’ tumors during treatment that were associated with how long they lived.
What do the results of the study mean?
The types of genetic and molecular changes that occur during treatment in participants’ tumors can affect their response to treatment with BRAF and MEK inhibitors.This manuscript was funded by Pfizer.
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Anomalies cromosòmiques
Recte - Càncer - Tractament
Còlon - Càncer - Tractament
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
Other subheadings::Other subheadings::Other subheadings::/drug therapy
PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Mutation
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::mutación
A plain language summary of the molecular changes in the tumors of people with BRAF V600E–mutant colorectal cancer in the BEACON study
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion