2026-04-14T08:24:33Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/133692025-10-24T10:15:55Zcom_2072_378070com_2072_378040col_2072_378092

2025-10-24T10:15:55Z urn:hdl:11351/13369 Update on pediatric liver transplantation in Europe 2022: An ELITA-ESPGHAN report Junge, Norman Karam, Vincent Hartog, Hermien ADAM, René Cailliez, Valérie Indolfi, Giuseppe quintero, jesus Fetge - Trasplantació Infants Avaluació de resultats (Assistència sanitària) Donants d'òrgans Empelt contra l'hoste, Malaltia de l' ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Digestive System Surgical Procedures::Surgical Procedures, Operative::Surgical Procedures, Operative::Liver Transplantation ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome NAMED GROUPS::Persons::Tissue Donors::Living Donors PHENOMENA AND PROCESSES::Immune System Phenomena::Transplantation Immunology::Host vs Graft Reaction::Graft Survival NAMED GROUPS::Persons::Age Groups::Child TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos del sistema digestivo::intervenciones quirúrgicas::intervenciones quirúrgicas::trasplante de hígado TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento DENOMINACIONES DE GRUPOS::personas::donantes de tejidos::donantes vivos FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunología del trasplante::reacción huésped contra injerto::supervivencia del injerto DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño Graft survival; Living‐donor liver transplantation; Patient survival Supervivencia del injerto; Trasplante de hígado de donante vivo; Supervivencia del paciente Supervivència de l'empelt; Trasplantament de fetge de donant viu; Supervivència del pacient Objectives The European Liver Transplant Registry (ELTR) has been collecting data on liver transplantation (LT) in Europe since 1968. The aim of this report is to outline the number, techniques utilized, indications for, and outcomes of pediatric LT (pLT) in Europe, focusing on the Year 2022 in comparison to the preceding 5 years. Methods Data were obtained from ELTR and Eurotransplant (ET). Summary statistics were performed. Results In 2022, 585 pLTs were performed in Europe. The annual number of pLT decreased for the third consecutive year. Living donor LT represented 34% (n = 201) of pLT. The proportion of living donation (LD) remained stable over time. The major indication for pLT in Europe is biliary atresia. Donor age is increasing overall and is associated with worse graft survival. Graft and patient survival were impacted by both types of donors and types of grafts, and were significantly worse after re-transplantation. Most graft failures (77%) and deaths (82%) occurred within the first 6 months after pLT. Conclusion Annual numbers of pLT in Europe are decreasing over time. Given that the proportion of LD has remained stable, the shortage of deceased donor organs may not be the major reason for this trend, and other factors play a role. A focus on improving perioperative care is needed because the risk of graft loss and mortality is highest in the first 6 months after transplantation. New techniques like ex-situ machine perfusion may help mitigate risks with declining quality of deceased donor liver grafts. 2025-10-24T10:15:55Z 2025-10-24T10:15:55Z 2025-07-08T07:59:01Z 2025-07-08T07:59:01Z 2025-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/13369 Journal of Pediatric Gastroenterology and Nutrition;81(1) https://doi.org/10.1002/jpn3.70065 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Wiley Scientia