2026-04-13T00:05:40Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/131712025-10-24T10:37:23Zcom_2072_378070com_2072_378040col_2072_378092

2025-10-24T10:37:23Z urn:hdl:11351/13171 Spironolactone inhibits the NLRP1 inflammasome and alleviates defective erythropoiesis in Diamond-Blackfan anemia Rodríguez Ruiz, Lola Lozano Gil, Juan Manuel Ocaña Esparza, Maria Ana, Ana María Conesa Hernández Perez Oliva, Ana Belen Fuster, José L. Murillo-Sanjuán, Laura Diaz de Heredia, Cristina Diürètics - Ús terapèutic Anèmia - Tractament Eritropoesi DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Anemia::Anemia, Aplastic::Anemia, Hypoplastic, Congenital::Anemia, Diamond-Blackfan PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Differentiation::Hematopoiesis::Erythropoiesis CHEMICALS AND DRUGS::Organic Chemicals::Lactones::Spironolactone Other subheadings::Other subheadings::/therapeutic use CHEMICALS AND DRUGS::Macromolecular Substances::Multiprotein Complexes::Inflammasomes ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::anemia::anemia aplásica::anemia hipoplásica congénita::anemia de Diamond-Blackfan FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::diferenciación celular::hematopoyesis::eritropoyesis COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::lactonas::espironolactona Otros calificadores::Otros calificadores::/uso terapéutico COMPUESTOS QUÍMICOS Y DROGAS::sustancias macromoleculares::complejos multiproteicos::inflamasomas Spironolactone; Defective erythropoiesis; Diamond-Blackfan anemia Espironolactona; Eritropoiesi defectuosa; Anèmia de Diamond-Blackfan Espironolactona; Eritropoyesis defectuosa; Anemia de Diamond-Blackfan This work was supported by Fundación Séneca, Agencia de Ciencia y Tecnología de la Región de Murcia (grants 20793/PI/18 and 21887/PI/22 to V. M.), MCIN/AEI/10.13039/501100011033 (research grant 2020-113660RB-I00 to V. M., Juan de la Cierva-Incorporación postdoctoral contract to S. D. T., and PhD fellowship to L. R.-R.), ISCIII (Miguel Servet CP20/00028, CP21/00028, and CP23/00049 to A. B. P.-O., D. G.-M., and S.D.T., respectively), the Spanish Ministry of Universities (PhD fellowship to J. M. L.-G.), Diamond-Blackfan Anemia Foundation, Inc. (DBAF), Universidad de Murcia (research initiation fellowships to M.O.-E. and A.M.C.-H.), and Consejería de Salud de la CARM (postdoctoral contract to A. M.-L.). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. 2025-10-24T10:37:23Z 2025-10-24T10:37:23Z 2025-05-30T09:26:26Z 2025-05-30T09:26:26Z 2025-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/13171 HemaSphere;9(4) https://doi.org/10.1002/hem3.70131 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Wiley Scientia