2026-04-17T03:44:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/131452025-10-24T10:44:03Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Dirschka, Thomas author Ardigo, Marco author Fargnoli, Maria Concetta author Gilaberte, Yolanda author Hadshiew, Ina author Ferrandiz-Pulido, Carla author 2025-05-26T13:14:25Z 2025-05-26T13:14:25Z 2025 Actinic keratoses; Lesion-directed treatment; Modified Delphi consensus Queratosis actínica; Tratamiento dirigido a la lesión; Consenso Delphi modificado Queratosis actínica; Tractament dirigit a la lesió; Consens Delphi modificat Purpose Actinic keratosis (AK) is the main precursor of invasive cutaneous squamous cell carcinoma (cSCC). Since it is impossible to predict which lesions will progress to cSCC, early treatment of AK is crucial. Although AK treatments are effective, some are associated with local skin reactions that may impact treatment compliance and effectiveness. The aim of this modified Delphi study was to review the efficacy and safety of the different AK treatments, gain an understanding of the dermatologists’ perspectives on their use, and provide guidelines for clinical practice. Materials and methods This document corresponds to a modified Delphi consensus survey, based on a literature review and a single round of questionnaire. Results The Delphi questionnaire was completed by 73 dermatologists from Germany, Italy, and Spain. Agreement was achieved for 78% of statements, while 11% showed discrepancies or were rejected. Conclusions Key findings emphasize the importance of patient-centered approaches and treatment attributes beyond efficacy (e.g. tolerability or adherence). Understanding the mechanisms of action of treatments is vital for managing patients’ and clinicians’ expectations and optimizing outcomes. Alternative strategies for evaluating efficacy, including the Actinic Keratosis Area and Severity Index (AKASI) score and lesion reduction from baseline, were also highlighted. This work was supported by Almirall. http://hdl.handle.net/11351/13145 Qüestionaris Mètode Delphi Pell - Càncer - Tractament Queratosi - Tractament ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires INFORMATION SCIENCE::Information Science::Systems Analysis::Delphi Technique DISEASES::Neoplasms::Precancerous Conditions::Keratosis, Actinic Other subheadings::Other subheadings::/therapy DISEASES::Neoplasms::Neoplasms by Site::Skin Neoplasms TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios CIENCIA DE LA INFORMACIÓN::Ciencias de la información::análisis de sistemas::técnica Delfos ENFERMEDADES::neoplasias::lesiones precancerosas::queratosis actínica Otros calificadores::Otros calificadores::/terapia ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias cutáneas Reshaping treatment paradigm in actinic keratosis by using a modified Delphi questionnaire