2026-04-17T05:20:45Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/130542025-10-24T10:25:51Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Sossa-Alarcón, María Camila
author
Gutierrez Gaitan, Monica Paola
author
Becerra Uribe, Natalia
author
Ortegon, Luz Yessenia
author
David, María Camila
author
Naranjo Vanegas, Melisa Sofía
author
Soriano-Arandes, Antoni
author
Melendo, Susana
2025-10-24T10:25:51Z
2025-10-24T10:25:51Z
2025-05-08T11:19:59Z2025-05-08T11:19:59Z2025-03
http://hdl.handle.net/11351/13054
COVID-19; Inpatients; PediatricsCOVID-19; Pacientes hospitalizados; PediatríaCOVID-19; Pacients hospitalitzats; PediatriaObjective: To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study.
Methods: We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes.
Results: A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries.
Conclusion: Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies.The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was fund by the Pediatrics Department at the Universidad de los Andes and Fundación Santa Fe de Bogotá and Pan American Health Organization. The sponsors were not directly involved in the study, meaning that they had no role in the study design, data collection, and report writing.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
COVID-19 (Malaltia)
Infants
Fenotip
Hospitals - Ingressos i altes
Anàlisi de conglomerats
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Hospitalization
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Cluster Analysis
NAMED GROUPS::Persons::Age Groups::Child
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::hospitalización
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis por grupos
DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño
Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion