2026-04-13T19:02:32Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/130542025-10-24T10:25:51Zcom_2072_378070com_2072_378040col_2072_378092

2025-10-24T10:25:51Z urn:hdl:11351/13054 Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study Sossa-Alarcón, María Camila Gutierrez Gaitan, Monica Paola Becerra Uribe, Natalia Ortegon, Luz Yessenia David, María Camila Naranjo Vanegas, Melisa Sofía Soriano-Arandes, Antoni Melendo, Susana COVID-19 (Malaltia) Infants Fenotip Hospitals - Ingressos i altes Anàlisi de conglomerats DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Hospitalization ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Cluster Analysis NAMED GROUPS::Persons::Age Groups::Child ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::hospitalización TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis por grupos DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño COVID-19; Inpatients; Pediatrics COVID-19; Pacientes hospitalizados; Pediatría COVID-19; Pacients hospitalitzats; Pediatria Objective: To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study. Methods: We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes. Results: A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries. Conclusion: Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies. The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was fund by the Pediatrics Department at the Universidad de los Andes and Fundación Santa Fe de Bogotá and Pan American Health Organization. The sponsors were not directly involved in the study, meaning that they had no role in the study design, data collection, and report writing. 2025-10-24T10:25:51Z 2025-10-24T10:25:51Z 2025-05-08T11:19:59Z 2025-05-08T11:19:59Z 2025-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/13054 International Journal of Public Health;70 https://doi.org/10.3389/ijph.2025.1607246 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Frontiers Media Scientia