2026-04-17T06:32:15Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/128832025-10-01T01:33:45Zcom_2072_378071com_2072_378040col_2072_378097

00925njm 22002777a 4500 dc Mayer, Jutta author Kohlhas, Laura author Stermann, Jacek author Medda, Juliane E. author Brandt, Geva A. author Grimm, Oliver author Palacio Sanchez, Judit author Richarte Fernández, Vanesa author Ramos-Quiroga, Josep Antoni author 2025-04-02T12:35:29Z 2025-04-02T12:35:29Z 2024 2025-04 Attention-deficit-hyperactivity disorder; Bright light therapy; Depression Trastorno por déficit de atención e hiperactividad; Terapia de luz brillante; Depresión Trastorn per dèficit d'atenció i hiperactivitat; Teràpia de llum brillant; Depressió Depression is common in attention-deficit/hyperactivity disorder (ADHD), but preventive behavioural interventions are lacking. This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)—both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system—for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven participants aged 14–45 years were randomised to 10-week add-on intervention of either BLT (10,000 lx; daily 30-min sessions) (n = 70), EI (aerobic and muscle-strengthening activities 3 days/ week) (n = 69), or treatment-as-usual (TAU) (n = 68), of whom 165 (80%) were retained (BLT: n = 54; EI: n = 52; TAU: n = 59). Intervention adherence (i.e. ≥ 80% completed sessions) was very low for both BLT (n = 13, 22%) and EI (n = 4, 7%). Usability of the m-health system to conduct interventions was limited as indicated by objective and subjective data. Safety was high and comparable between groups. Changes in depressive symptoms (assessed via observer-blind ratings, Inventory of Depressive Symptomatology) between baseline and end of intervention were small (BLT: −0.124 [95% CI: −2.219, 1.971], EI: −2.646 [95% CI: −4.777, −0.515], TAU: −1.428 [95% CI: −3.381, 0.526]) with no group differences [F(2,153) = 1.45, p = 0.2384]. These findings suggest that the m-health approach did not achieve feasibility of EI and BLT in young people with ADHD. Prior to designing efficacy studies, strategies how to achieve high intervention adherence should be specifically investigated in this patient group. Open Access funding enabled and organized by Projekt DEAL. The research has received funding from the EU Framework Programme for Research and Innovation, Horizon 2020 under grant agreement no. 667303 (CoCA). F.B.O. research activity was also supported by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Unit of Excellence on Exercise, Nutrition and Health (UCEENS). The funding sources had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Trastorn per dèficit d'atenció amb hiperactivitat - Tractament Adolescents Exercici terapèutic Fototeràpia Depressió psíquica - Tractament PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity Other subheadings::Other subheadings::/therapy PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression Other subheadings::Other subheadings::/therapy ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Physical Therapy Modalities::Therapeutics::Exercise Therapy ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Phototherapy NAMED GROUPS::Persons::Age Groups::Adolescent PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad Otros calificadores::Otros calificadores::/terapia PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::conducta::síntomas conductuales::depresión Otros calificadores::Otros calificadores::/terapia TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::modalidades de fisioterapia::terapéutica::tratamiento por actividad física TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::fototerapia DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescente Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder: a multicentre, three-arm, randomised controlled, pilot phase-IIa trial