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oai:recercat.cat:11351/128652025-10-24T10:42:52Zcom_2072_378070com_2072_378040com_2072_451669col_2072_378092col_2072_451670

Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence Verdaguer-Faja, Júlia Guerra-Amor, Álvaro Masferrer i Niubò, Emili Lopez Castillo, Daniel Deza, Gustavo Leal, Lorena Ruiz-Salas, Verónica Yébenes, Mireia Marqués-Martin, Laura Baliu, Carola Castany, Anna Toll, Agustí JAKA, ANE Ferrandiz-Pulido, Carla Marti-Marti, Ignasi Boada, Aram [Verdaguer-Faja J, Boada A, Ferrándiz-Pulido C, Jaka A] Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain. [Guerra-Amor A] Servei de Dermatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Abril-Pérez C, Botella-Estrada R] Department of Dermatology, Hospital Universitario La Fe, Instituto de Investigación Sanitaria La Fe (ISS La Fe), Valencia, Spain. [Masferrer E, López-Castillo D] Department of Dermatology, Hospital Universitari Mútua Terrassa, Terrassa, Spain. [Deza G, Leal L] Department of Dermatology, Hospital del Mar, Institut Mar d'Investigacions Mèdiques, Barcelona, Spain. [Marti-Marti I, Toll A] Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. [Ruiz-Salas V] Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Yébenes M] Department of Dermatology, Hospital Parc Taulí, Sabadell, Spain. [Marques Martin L] Department of Dermatology, Hospital de Santa Caterina, Girona, Spain. [Baliu C, Castany A] Department of Dermatology, Hospital Universitari d'Igualada, Igualada, Spain Institut d'Assistència Sanitària Tumors Cuir cabellut - Malalties Pell - Càncer DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Carcinoma, Squamous Cell DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Scalp Dermatoses DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Neoplastic Processes::Neoplasm Recurrence, Local Other subheadings::Other subheadings::Other subheadings::/epidemiology DISEASES::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias glandulares y epiteliales::carcinoma::carcinoma de células escamosas ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatosis del cuero cabelludo ENFERMEDADES::neoplasias::procesos neoplásicos::recurrencia neoplásica local Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de cabeza y cuello Carcinoma cutani de cèl·lules escamoses; Cuir cabellut; Recurrència Cutaneous squamous cell carcinoma; Scalp; Recurrence Carcinoma cutáneo de células escamosas; Cuero cabelludo; Recurrencia Background.Consensus is lacking on adequate deep histological margins in cutaneous squamous cell carcinoma (cSCC). Deep clearance for tumours located on the scalp is limited by anatomic constraints.Objective To determine whether clear but close deep histological margins (<1 mm) confer a higher risk of recurrence in cSCCs of the scalp treated by wide local excision, compared to deep histological margins ≥1 mm.Methods:Multicentre retrospective observational cohort study and multivariate competing risk analysis to evaluate risk factors for recurrence.Results:In total, 295 patients with 338 cSCCs were included. Close deep histological margins were not associated with an increased cumulative incidence of recurrence (subhazard ratio [SHR] 1.96 [95% CI 0.87–4.41]). However, an increased risk of recurrence was observed for those tumours that presented concurrent invasion of the galea aponeurotica and close deep margins, as opposed to patients without these factors (SHR 3.52 [1.24–10.01]). Tumours with clear but close peripheral margins (<1 mm) also had higher risk of recurrence (SHR 5.01 [1.68–14.97]).Limitations:Retrospective observational study based on pathology reports.Conclusions:Deep histological margins <1 mm do not confer a greater risk of recurrence as long as the tumour is completely excised and the galea aponeurotica is not involved. Surgical excision of cSCC on the scalp should include the galea to ensure proper assessment of deep margins. 2025-04-01T11:03:34Z 2025-04-01T11:03:34Z 2024-07-22 info:eu-repo/semantics/article Verdaguer-Faja J, Guerra-Amor Á, Ferrándiz-Pulido C, Abril-Pérez C, Botella Estrada R, Masferrer E, et al. Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence. Journal of the European Academy of Dermatology and Venereology 2024 Apr;39(4):855-864. 1468-3083 http://hdl.handle.net/11351/12865 10.1111/jdv.20250 39036869 http://hdl.handle.net/11351/12865 eng J Eur Acad Dermatol Venereol;39(4) https://doi.org/10.1111/jdv.20250 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess pdf application/pdf Wiley Scientia