2026-04-13T07:38:25Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/128632025-10-24T10:39:08Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc de la Torre-Montero, Julio C. author Serra López, Jorgina author Alvarez-Garcia, Raquel author Battle-Vidal, Magdalena author Gil-Gómez, Nieves author Beorlegui, Patricia author Peñuelas Saiz, Angeles author 2025-04-01T09:54:35Z 2025-04-01T09:54:35Z 2025-02 Cancer; Chemotherapy; Nutritional status Càncer; Quimioteràpia; Estat nutricional Cáncer; Quimioterapia; Estado nutricional Objectives: Malnutrition is a prevalent condition in cancer patients that significantly impacts patients' clinical outcomes and health-related quality of life (HR-QoL). The outcome was to characterize the nutritional status by describing the prevalence of malnutrition (mild, moderate, or severe) and its risk in outpatient cancer patients. Methods: Multicenter, prospective, cross-sectional, descriptive, two-cohort study conducted on consecutive adult patients with locally advanced or metastatic solid tumors (stages III-IV). The study was conducted in 10 Spanish hospitals distributed all over the Spanish geography, with a recruitment period of 5 months (between April and September 2020). Study patients were divided into two groups according to their cancer therapy: group A, patients who underwent immunotherapy, and group B, patients who received combined therapy (immunotherapy plus chemotherapy and radiotherapy). Results: A total of 585 patients were included. The proportion of patients at risk of malnutrition was notably more significant in the combination group (chemotherapy and/or radiotherapy) than in the immunotherapy-only group (28.3% versus 58.5%, respectively, P < .0001). According to this evaluation the highest proportion of patients at risk were those with pancreatic cancer (51 patients; 89.5%), followed by large intestine cancer (52 patients; 55.3%) and lung cancer (56 patients; 29.3%), P < .0001. Conclusions: Patients treated with only immunotherapy seemed to have better nutritional status, which indicated health-related quality of life improvement. Additionally, there was a trend associating nutritional status with tumor location. Treatment strategy, treatment duration, performance status, and treatment location were independently associated with malnutrition. Implications for nursing practice: Integrating nutritional assessment into routine clinical practice will improve the quality of life of oncology patients. An integrative approach to health improves overall results in terms of nutritional status and improved quality of life and shows that daily living activities are more satisfactory for patients with nursing interventions. Nursing interventions are consistent with an educational approach to patients as long as the interventions described in international guidelines are detailed in the framework of the patient care. This work was supported by Baxter Healthcare Corporation INC competitive program grant. The funding body provides funds for research assistant CRO and engagement of statistical support from Clinical Research Associates. It pays for all study-related expenses such as reimbursements of study participants and manuscripts processing fees. The funders had no role in the study's design, collecting, analyzing, or interpreting data, writing the manuscript, or deciding to publish the results. http://hdl.handle.net/11351/12863 Pacients - Satisfacció Càncer - Immunoteràpia Càncer - Quimioteràpia Càncer - Radioteràpia Desnutrició DISEASES::Neoplasms Other subheadings::Other subheadings::/therapy HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life DISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Malnutrition ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy ENFERMEDADES::neoplasias Otros calificadores::Otros calificadores::/terapia ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida ENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::desnutrición TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia Nutritional Status in Locally Advanced or Metastatic Solid Cancer Patients Treated With Chemotherapy, Radiotherapy, and Immunotherapy in Spanish Outpatient Oncology Units